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Cytoneme-mediated signaling essential for tumorigenesis
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Cytoneme-mediated signaling essential for tumorigenesis
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Journal Article
Cytoneme-mediated signaling essential for tumorigenesis
2019
Overview
Communication between neoplastic cells and cells of their microenvironment is critical to cancer progression. To investigate the role of cytoneme-mediated signaling as a mechanism for distributing growth factor signaling proteins between tumor and tumor-associated cells, we analyzed EGFR and RET Drosophila tumor models and tested several genetic loss-of-function conditions that impair cytoneme-mediated signaling. Neuroglian, capricious, Irk2, SCAR, and diaphanous are genes that cytonemes require during normal development. Neuroglian and Capricious are cell adhesion proteins, Irk2 is a potassium channel, and SCAR and Diaphanous are actin-binding proteins, and the only process to which they are known to contribute jointly is cytoneme-mediated signaling. We observed that diminished function of any one of these genes suppressed tumor growth and increased organism survival. We also noted that EGFR-expressing tumor discs have abnormally extensive tracheation (respiratory tubes) and ectopically express Branchless (Bnl, a FGF) and FGFR. Bnl is a known inducer of tracheation that signals by a cytoneme-mediated process in other contexts, and we determined that exogenous over-expression of dominant negative FGFR suppressed tumor growth. Our results are consistent with the idea that cytonemes move signaling proteins between tumor and stromal cells and that cytoneme-mediated signaling is required for tumor growth and malignancy.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Animals
/ Cancer
/ Cell Transformation, Neoplastic - metabolism
/ Drosophila melanogaster - genetics
/ Drosophila Proteins - genetics
/ Drosophila Proteins - metabolism
/ Epidermal growth factor receptors
/ Fibroblast growth factor receptors
/ Genes
/ Insects
/ Intercellular Signaling Peptides and Proteins - metabolism
/ Medicine and Health Sciences
/ Neoplasm Metastasis - genetics
/ Proteins
/ Receptors, Invertebrate Peptide - metabolism
/ Research and Analysis Methods
/ Signal Transduction - physiology
/ Signaling peptides and proteins
/ Tumor Microenvironment - physiology
/ Tumors
