Journal Article

Imbalance between endothelial damage and repair capacity in chronic obstructive pulmonary disease

Paul, Tanja, Tura-Ceide, Olga, de Jover, Lluís, Barberà, Joan Albert, Blanco, Isabel, del Pozo, Roberto, Bonjoch, Cristina, Peinado, Victor I., García-Lucio, Jéssica, Coll-Bonfill, Núria

2018

Overview

Circulating endothelial microparticles (EMPs) and progenitor cells (PCs) are biological markers of endothelial function and endogenous repair capacity. The study was aimed to investigate whether COPD patients have an imbalance between EMPs to PCs compared to controls and to evaluate the effect of cigarette smoke on these circulating markers. Circulating EMPs and PCs were determined by flow cytometry in 27 nonsmokers, 20 smokers and 61 COPD patients with moderate to severe airflow obstruction. We compared total EMPs (CD31+CD42b-), apoptotic if they co-expressed Annexin-V+ or activated if they co-expressed CD62E+, circulating PCs (CD34+CD133+CD45+) and the EMPs/PCs ratio between groups. COPD patients presented increased levels of total and apoptotic circulating EMPs, and an increased EMPs/PCs ratio, compared with nonsmokers. Women had less circulating PCs than men through all groups and those with COPD showed lower levels of PCs than both control groups. In smokers, circulating EMPs and PCs did not differ from nonsmokers, being the EMPs/PCs ratio in an intermediate position between COPD and nonsmokers. We conclude that COPD patients present an imbalance between endothelial damage and repair capacity that might explain the frequent concurrence of cardiovascular disorders. Factors related to the disease itself and gender, rather than cigarette smoking, may account for this imbalance.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Air flow / Airflow / Apoptosis / Atherosclerosis / Bioindicators / Biology and Life Sciences / Biomarkers / Cardiovascular disease / Cardiovascular diseases / Causes of / CD34 antigen / CD45 antigen / Cells (biology) / Chronic obstructive lung disease / Chronic obstructive pulmonary disease / Cigarette smoke / Cigarette smoking / Cigarettes / Comparative analysis / Complications and side effects / Cytometry / Development and progression / Endothelium / Family medical history / Flow cytometry / Health aspects / Hospitals / Life assessment / Lung diseases / Medicine / Medicine and Health Sciences / Microparticles / Obstructive lung disease / Patients / Physiological aspects / Progenitor cells / Repair / Research and Analysis Methods / Risk factors / Smoke / Smoking / Stem cells