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A Hox complex activates and potentiates the Epidermal Growth Factor signaling pathway to specify Drosophila oenocytes
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A Hox complex activates and potentiates the Epidermal Growth Factor signaling pathway to specify Drosophila oenocytes
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A Hox complex activates and potentiates the Epidermal Growth Factor signaling pathway to specify Drosophila oenocytes
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Journal Article
A Hox complex activates and potentiates the Epidermal Growth Factor signaling pathway to specify Drosophila oenocytes
2017
Overview
Hox transcription factors specify distinct cell types along the anterior-posterior axis of metazoans by regulating target genes that modulate signaling pathways. A well-established example is the induction of Epidermal Growth Factor (EGF) signaling by an Abdominal-A (Abd-A) Hox complex during the specification of Drosophila hepatocyte-like cells (oenocytes). Previous studies revealed that Abd-A is non-cell autonomously required to promote oenocyte fate by directly activating a gene (rhomboid) that triggers EGF secretion from sensory organ precursor (SOP) cells. Neighboring cells that receive the EGF signal initiate a largely unknown pathway to promote oenocyte fate. Here, we show that Abd-A also plays a cell autonomous role in inducing oenocyte fate by activating the expression of the Pointed-P1 (PntP1) ETS transcription factor downstream of EGF signaling. Genetic studies demonstrate that both PntP1 and PntP2 are required for oenocyte specification. Moreover, we found that PntP1 contains a conserved enhancer (PntP1OE) that is activated in oenocyte precursor cells by EGF signaling via direct regulation by the Pnt transcription factors as well as a transcription factor complex consisting of Abd-A, Extradenticle, and Homothorax. Our findings demonstrate that the same Abd-A Hox complex required for sending the EGF signal from SOP cells, enhances the competency of receiving cells to select oenocyte cell fate by up-regulating PntP1. Since PntP1 is a downstream effector of EGF signaling, these findings provide insight into how a Hox factor can both trigger and potentiate the EGF signal to promote an essential cell fate along the body plan.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Animals
/ Cellular signal transduction
/ DNA-Binding Proteins - genetics
/ DNA-Binding Proteins - metabolism
/ Drosophila Proteins - genetics
/ Drosophila Proteins - metabolism
/ Epidermal Growth Factor - genetics
/ Epidermal Growth Factor - metabolism
/ Gene Expression Regulation, Developmental
/ Insects
/ Kinases
/ Nerve Tissue Proteins - genetics
/ Nerve Tissue Proteins - metabolism
/ Proto-Oncogene Proteins - genetics
/ Proto-Oncogene Proteins - metabolism
/ Research and Analysis Methods
/ Sense Organs - growth & development
/ Studies
