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Helicobacter pylori and colorectal cancer—A bacterium going abroad?
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Journal Article
Helicobacter pylori and colorectal cancer—A bacterium going abroad?
2019
Overview
Besides causing gastric cancer, which was officially acknowledged by the World Health Organization in 1994 [3], the presence of H. pylori has been associated with other diseases as well. Information on whether persistent infection was a consequence of antibiotic resistance, noncompliance to the applied antibiotic treatment, or reinfection during the study course was not further specified in the publication. [...]it would have been interesting to further define whether persistent H. pylori infection alone or together with associated epithelial damage in the stomach—such as atrophic gastritis, intestinal metaplasia, dysplasia, or even gastric cancer—was associated with colorectal adenoma incidence. [...]H. pylori infection could be involved in colorectal carcinogenesis by increasing the release of gastrin that may act as a mitogen. [...]H. pylori induces chronic inflammation in the stomach mucosa, thereby also elevating systemically inflammatory responses in the body [65, 66].
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Bacteria
/ Cancer
/ Colorectal Neoplasms - epidemiology
/ Colorectal Neoplasms - microbiology
/ Complications and side effects
/ Gastrin
/ Helicobacter Infections - complications
/ Helicobacter Infections - microbiology
/ Helicobacter pylori - pathogenicity
/ Humans
/ Medicine and Health Sciences
/ Mucosa
/ Pearls
/ Research and Analysis Methods
/ Stomach
/ Studies
/ Tumors
