Journal Article

Rational Prescribing in Primary Care (RaPP): A Cluster Randomized Trial of a Tailored Intervention

Bjørndal, Arild, Fretheim, Atle, Håvelsrud, Kari, Oxman, Andrew D, Kristoffersen, Doris T, Treweek, Shaun

2006

Overview

A gap exists between evidence and practice regarding the management of cardiovascular risk factors. This gap could be narrowed if systematically developed clinical practice guidelines were effectively implemented in clinical practice. We evaluated the effects of a tailored intervention to support the implementation of systematically developed guidelines for the use of antihypertensive and cholesterol-lowering drugs for the primary prevention of cardiovascular disease. We conducted a cluster-randomized trial comparing a tailored intervention to passive dissemination of guidelines in 146 general practices in two geographical areas in Norway. Each practice was randomized to either the tailored intervention (70 practices; 257 physicians) or control group (69 practices; 244 physicians). Patients started on medication for hypertension or hypercholesterolemia during the study period and all patients already on treatment that consulted their physician during the trial were included. A multifaceted intervention was tailored to address identified barriers to change. Key components were an educational outreach visit with audit and feedback, and computerized reminders linked to the medical record system. Pharmacists conducted the visits. Outcomes were measured for all eligible patients seen in the participating practices during 1 y before and after the intervention. The main outcomes were the proportions of (1) first-time prescriptions for hypertension where thiazides were prescribed, (2) patients assessed for cardiovascular risk before prescribing antihypertensive or cholesterol-lowering drugs, and (3) patients treated for hypertension or hypercholesterolemia for 3 mo or more who had achieved recommended treatment goals. The intervention led to an increase in adherence to guideline recommendations on choice of antihypertensive drug. Thiazides were prescribed to 17% of patients in the intervention group versus 11% in the control group (relative risk 1.94; 95% confidence interval 1.49-2.49, adjusted for baseline differences and clustering effect). Little or no differences were found for risk assessment prior to prescribing and for achievement of treatment goals. Our tailored intervention had a significant impact on prescribing of antihypertensive drugs, but was ineffective in improving the quality of other aspects of managing hypertension and hypercholesterolemia in primary care.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Anticholesteremic agents / Anticholesteremic Agents - therapeutic use / Antihypertensive Agents - therapeutic use / Antihypertensive drugs / Antihypertensives / Blood pressure / Cardiology/Cardiac Surgery / Cardiovascular diseases / Cardiovascular Diseases - etiology / Cardiovascular Diseases - prevention & control / Cardiovascular Medicine / Cholesterol / Chronic Disease Management / Clinical medicine / Clinical practice guidelines / Cluster Analysis / Confidence intervals / Drug Prescriptions / Drug therapy / Drug Utilization - statistics & numerical data / Epidemiology/Public Health / Family physicians / Family Practice - standards / Female / General Medicine / General Practice/Family Practice/Primary Care / Guideline Adherence / Health Economics / Health Policy / Health Promotion / Humans / Hypercholesterolemia - complications / Hypercholesterolemia - drug therapy / Hypertension / Hypertension - complications / Hypertension - drug therapy / Male / Middle Aged / Norway / Practice Guidelines as Topic / Practice Patterns, Physicians' - statistics & numerical data / Prescription drugs / Primary Care / Primary Health Care - standards / Research Design / Risk Assessment / Risk Factors / Sodium Chloride Symporter Inhibitors - therapeutic use