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Coupled oscillators control morning and evening locomotor behaviour of Drosophila
by
Agosto, J
, Rosbash, M
, Stoleru, D
, Peng, Y
in
Animals
/ Behavior
/ Behavior, Animal - physiology
/ Biological and medical sciences
/ brain
/ circadian neurons
/ Circadian rhythm
/ Circadian Rhythm - genetics
/ Circadian Rhythm - physiology
/ Circadian rhythms
/ Cryptochromes
/ dorsal lateral neurons
/ Drosophila
/ Drosophila melanogaster
/ Drosophila melanogaster - cytology
/ Drosophila melanogaster - genetics
/ Drosophila melanogaster - physiology
/ Drosophila Proteins - genetics
/ Drosophila Proteins - metabolism
/ Eye Proteins - metabolism
/ Fundamental and applied biological sciences. Psychology
/ gene expression
/ Genotype
/ Humanities and Social Sciences
/ insect behavior
/ Insects
/ letter
/ locomotion
/ Motor Activity - genetics
/ Motor Activity - physiology
/ multidisciplinary
/ Neurology
/ Neurons
/ Neurons - cytology
/ Neurons - physiology
/ neuropeptides
/ Neuropeptides - genetics
/ Neuropeptides - metabolism
/ PDF neuropeptide
/ Peptides
/ Photoreceptor Cells, Invertebrate - metabolism
/ Receptors, G-Protein-Coupled
/ Science
/ Science (multidisciplinary)
/ Time Factors
/ transgenes
/ transgenic insects
/ Vertebrates: nervous system and sense organs
2004
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Coupled oscillators control morning and evening locomotor behaviour of Drosophila
by
Agosto, J
, Rosbash, M
, Stoleru, D
, Peng, Y
in
Animals
/ Behavior
/ Behavior, Animal - physiology
/ Biological and medical sciences
/ brain
/ circadian neurons
/ Circadian rhythm
/ Circadian Rhythm - genetics
/ Circadian Rhythm - physiology
/ Circadian rhythms
/ Cryptochromes
/ dorsal lateral neurons
/ Drosophila
/ Drosophila melanogaster
/ Drosophila melanogaster - cytology
/ Drosophila melanogaster - genetics
/ Drosophila melanogaster - physiology
/ Drosophila Proteins - genetics
/ Drosophila Proteins - metabolism
/ Eye Proteins - metabolism
/ Fundamental and applied biological sciences. Psychology
/ gene expression
/ Genotype
/ Humanities and Social Sciences
/ insect behavior
/ Insects
/ letter
/ locomotion
/ Motor Activity - genetics
/ Motor Activity - physiology
/ multidisciplinary
/ Neurology
/ Neurons
/ Neurons - cytology
/ Neurons - physiology
/ neuropeptides
/ Neuropeptides - genetics
/ Neuropeptides - metabolism
/ PDF neuropeptide
/ Peptides
/ Photoreceptor Cells, Invertebrate - metabolism
/ Receptors, G-Protein-Coupled
/ Science
/ Science (multidisciplinary)
/ Time Factors
/ transgenes
/ transgenic insects
/ Vertebrates: nervous system and sense organs
2004
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Coupled oscillators control morning and evening locomotor behaviour of Drosophila
by
Agosto, J
, Rosbash, M
, Stoleru, D
, Peng, Y
in
Animals
/ Behavior
/ Behavior, Animal - physiology
/ Biological and medical sciences
/ brain
/ circadian neurons
/ Circadian rhythm
/ Circadian Rhythm - genetics
/ Circadian Rhythm - physiology
/ Circadian rhythms
/ Cryptochromes
/ dorsal lateral neurons
/ Drosophila
/ Drosophila melanogaster
/ Drosophila melanogaster - cytology
/ Drosophila melanogaster - genetics
/ Drosophila melanogaster - physiology
/ Drosophila Proteins - genetics
/ Drosophila Proteins - metabolism
/ Eye Proteins - metabolism
/ Fundamental and applied biological sciences. Psychology
/ gene expression
/ Genotype
/ Humanities and Social Sciences
/ insect behavior
/ Insects
/ letter
/ locomotion
/ Motor Activity - genetics
/ Motor Activity - physiology
/ multidisciplinary
/ Neurology
/ Neurons
/ Neurons - cytology
/ Neurons - physiology
/ neuropeptides
/ Neuropeptides - genetics
/ Neuropeptides - metabolism
/ PDF neuropeptide
/ Peptides
/ Photoreceptor Cells, Invertebrate - metabolism
/ Receptors, G-Protein-Coupled
/ Science
/ Science (multidisciplinary)
/ Time Factors
/ transgenes
/ transgenic insects
/ Vertebrates: nervous system and sense organs
2004
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Coupled oscillators control morning and evening locomotor behaviour of Drosophila
Journal Article
Coupled oscillators control morning and evening locomotor behaviour of Drosophila
2004
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Overview
Daily rhythms of physiology and behaviour are precisely timed by an endogenous circadian clock. These include separate bouts of morning and evening activity, characteristic of Drosophila melanogaster and many other taxa, including mammals. Whereas multiple oscillators have long been proposed to orchestrate such complex behavioural programmes, their nature and interplay have remained elusive. By using cell-specific ablation, we show that the timing of morning and evening activity in Drosophila derives from two distinct groups of circadian neurons: morning activity from the ventral lateral neurons that express the neuropeptide PDF, and evening activity from another group of cells, including the dorsal lateral neurons. Although the two oscillators can function autonomously, cell-specific rescue experiments with circadian clock mutants indicate that they are functionally coupled.
Publisher
Nature Publishing Group UK,Nature Publishing,Nature Publishing Group
Subject
/ Behavior
/ Behavior, Animal - physiology
/ Biological and medical sciences
/ brain
/ Circadian Rhythm - physiology
/ Drosophila melanogaster - cytology
/ Drosophila melanogaster - genetics
/ Drosophila melanogaster - physiology
/ Drosophila Proteins - genetics
/ Drosophila Proteins - metabolism
/ Fundamental and applied biological sciences. Psychology
/ Genotype
/ Humanities and Social Sciences
/ Insects
/ letter
/ Neurons
/ Peptides
/ Photoreceptor Cells, Invertebrate - metabolism
/ Receptors, G-Protein-Coupled
/ Science
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