Journal Article

Associations of healthy eating patterns with biological aging: national health and nutrition examination survey (NHANES) 1999–2018

Li, Lin, Li, Ying, Qi, Xiang, Yan, Xuemin, Pan, Sijia, Wang, Xuanyang, Li, Ran, Cheng, Licheng, Zhang, Jia

2024

Overview

Background Healthy dietary patterns have been negatively associated with methylation-based measures of biological age, yet previous investigations have been unable to establish the relationship between them and biological aging assessed through blood chemistry-based clinical biomarkers. We sought to assess the associations of 4 dietary metrics with 4 measures of biological age. Methods Among 16,666 participants in NHANES 1999–2018, 4 dietary metrics [Dietary inflammatory index (DII), Dietary approaches to stop hypertension index (DASH), Alternate mediterranean diet score (aMED), and Healthy eating index-2015 (HEI-2015)] were calculated through the ‘dietaryindex’ R package. Twelve blood chemistry parameters were utilized to compute 4 indicators of biological age [homeostatic dysregulation (HD), allostatic load (AL), Klemera–Doubal method (KDM), and phenotypic age (PA)]. Binomial logistic regression models and restricted cubic spline (RCS) regression were employed to evaluate the associations. Results All 4 dietary metrics were significantly associated with biological age acceleration or deceleration. In comparison to the lowest DII, the odds ratios (ORs) for accelerated HD, AL, KDM, and PA were 1.25 (1.08,1.45), 1.29 (1.11,1.50), 1.34 (1.08,1.65), and 1.61 (1.39,1.87) for the highest. The multivariable-adjusted ORs of the highest quartile of DASH, aMED, and HEI-2015 were 0.85 (0.73,0.97), 0.88 (0.74,1.04), and 0.84 (0.74,0.96) for HD, 0.64 (0.54,0.75), 0.61 (0.52,0.72), and 0.70 (0.59,0.82) for AL, 0.68 (0.54,0.85), 0.62 (0.50,0.76), and 0.71 (0.58,0.87) for KDM, and 0.50 (0.42,0.59), 0.64 (0.54,0.76), and 0.51 (0.44,0.58) for PA when compared with the lowest level. The findings were validated by the best-fitting dose-response curves for the associations. Among participants consuming dietary supplements ( P interaction < 0.05), the positive effects of a healthy dietary pattern on biological aging were more pronounced. Systemic immune inflammation index (SII) and atherogenic index of plasma (AIP) were identified as being involved in and mediating the associations. Conclusions Biological aging assessed through blood chemistry-based clinical biomarkers is negatively associated with diet quality. The anti-aging benefits of improving the diet may be due to its ability to reduce inflammation and lower blood lipids.

• Publisher: BioMed Central,BioMed Central Ltd,BMC
• Subject: Adult / Aged / Aging - physiology / Anti-inflammatory diet / Biological age / Biological aging / biomarkers / Biomarkers - blood / blood / blood chemistry / Blood lipids / Clinical Nutrition / Diet / Diet, Healthy - methods / Diet, Healthy - statistics & numerical data / Dietary Approaches To Stop Hypertension - methods / Dietary Approaches To Stop Hypertension - statistics & numerical data / Dietary metrics / Dietary supplements / dose response / eating habits / Female / food quality / Health aspects / Health Promotion and Disease Prevention / Health surveys / Healthy eating patterns / Humans / Hypertension / inflammation / Longevity / Male / Mediation / Medicine / Medicine & Public Health / Mediterranean diet / Methods / Methylation / Middle Aged / National Health and Nutrition Examination Survey / National Health and Nutrition Examination Survey (NHANES) / Natural foods / Nutrition Surveys - methods / Nutrition Surveys - statistics & numerical data / phenotype / Physiological aspects / regression analysis / Surveys / United States