Journal Article

Novel Association of ABO Histo-Blood Group Antigen with Soluble ICAM-1: Results of a Genome-Wide Association Study of 6,578 Women

Badola, Sunita, Miletich, Joseph P., Kellogg, Mark, Rifai, Nader, Paré, Guillaume, Chasman, Daniel I., Ridker, Paul M., Zee, Robert Y. L.

2008

Overview

While circulating levels of soluble Intercellular Adhesion Molecule 1 (sICAM-1) have been associated with diverse conditions including myocardial infarction, stroke, malaria, and diabetes, comprehensive analysis of the common genetic determinants of sICAM-1 is not available. In a genome-wide association study conducted among 6,578 participants in the Women's Genome Health Study, we find that three SNPs at the ICAM1 (19p13.2) locus (rs1799969, rs5498 and rs281437) are non-redundantly associated with plasma sICAM-1 concentrations at a genome-wide significance level (P<5x10(-8)), thus extending prior results from linkage and candidate gene studies. We also find that a single SNP (rs507666, P = 5.1x10(-29)) at the ABO (9q34.2) locus is highly correlated with sICAM-1 concentrations. The novel association at the ABO locus provides evidence for a previously unknown regulatory role of histo-blood group antigens in inflammatory adhesion processes.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: ABO Blood-Group System - genetics / ABO Blood-Group System - immunology / ABO Blood-Group System - metabolism / Blood / Cancer / Cardiovascular disease / Cardiovascular Disorders/Cardiovascular Diseases in Women / Cardiovascular Disorders/Myocardial Infarction / Charitable foundations / Female / Genes / Genetic Linkage / Genetic Variation / Genetics and Genomics/Complex Traits / Genetics and Genomics/Genetics of the Immune System / Genome, Human / Genomes / Hematology/Blood Transfusion / Humans / Infectious Diseases/Tropical and Travel-Associated Diseases / Intercellular Adhesion Molecule-1 - blood / Intercellular Adhesion Molecule-1 - genetics / Malaria / Mortality / Myocardial Infarction - immunology / Myocardial Infarction - metabolism / Plasma / Polymorphism, Single Nucleotide / Proteins / Solubility / Stroke / Women's Health / Womens health