Journal Article

Consumption of a dietary portfolio of cholesterol lowering foods improves blood lipids without affecting concentrations of fat soluble compounds

Bashyam, Balachandran, Patel, Darshna, Frohlich, Jiri, Josse, Robert G, Kendall, Cyril WC, Ramprasath, Vanu R, Leiter, Lawrence A, Jones, Peter JH, Connelly, Philip W, Ireland, Chris, Abdulnour, Shahad, Vidgen, Edward, Jenkins, David JA, Couture, Patrick, Srichaikul, Korbua, de Souza, Russell J, Faulkner, Dorothea, Cermakova, Luba, Lamarche, Benoit

2014

Overview

BACKGROUND: Consumption of a cholesterol lowering dietary portfolio including plant sterols (PS), viscous fibre, soy proteins and nuts for 6 months improves blood lipid profile. Plant sterols reduce blood cholesterol by inhibiting intestinal cholesterol absorption and concerns have been raised whether PS consumption reduces fat soluble vitamin absorption. OBJECTIVE: The objective was to determine effects of consumption of a cholesterol lowering dietary portfolio on circulating concentrations of PS and fat soluble vitamins. METHODS: Using a parallel design study, 351 hyperlipidemic participants from 4 centres across Canada were randomized to 1 of 3 groups. Participants followed dietary advice with control or portfolio diet. Participants on routine and intensive portfolio involved 2 and 7 clinic visits, respectively, over 6 months. RESULTS: No changes in plasma concentrations of α and γ tocopherol, lutein, lycopene and retinol, but decreased β-carotene concentrations were observed with intensive (week 12:p = 0.045; week 24:p = 0.039) and routine (week 12:p = 0.031; week 24:p = 0.078) portfolio groups compared to control. However, cholesterol adjusted β-carotene and fat soluble compound concentrations were not different compared to control. Plasma PS concentrations were increased with intensive (campesterol:p = 0.012; β-sitosterol:p = 0.035) and routine (campesterol: p = 0.034; β-sitosterol: p = 0.080) portfolio groups compared to control. Plasma cholesterol-adjusted campesterol and β-sitosterol concentrations were negatively correlated (p < 0.001) with total and LDL-C levels. CONCLUSION: Results demonstrate that consuming a portfolio diet reduces serum total and LDL-C levels while increasing PS values, without altering fat soluble compounds concentrations. The extent of increments of PS with the current study are not deleterious and also maintaining optimum levels of fat soluble vitamins are of paramount necessity to maintain overall metabolism and health. Results indicate portfolio diet as one of the best options for CVD risk reduction.

• Publisher: Springer-Verlag,BioMed Central,BioMed Central Ltd,Springer Nature B.V
• Subject: Absorption / Adult / Beta carotene / beta Carotene - blood / beta-sitosterol / Blood / blood lipids / blood serum / campesterol / Canada / Carotenoids - blood / Cholesterol / Cholesterol - administration & dosage / Cholesterol - analogs & derivatives / Cholesterol - blood / Cholesterol, HDL - blood / Cholesterol, LDL - blood / Clinical Nutrition / correlation / Diet / Dietary Fiber - administration & dosage / experimental design / Feeding Behavior / Female / Follow-Up Studies / foods / Health aspects / Health Promotion and Disease Prevention / Humans / Hyperlipidemias - diet therapy / Investment companies / Lipids / lutein / Lutein - blood / lycopene / Male / Measurement / Medical research / Medicine / Medicine & Public Health / metabolism / Middle Aged / Nuts / Physiological aspects / Phytosterols - administration & dosage / Phytosterols - blood / Risk reduction / Rodents / Single-Blind Method / Sitosterols - administration & dosage / Sitosterols - blood / soy protein / Studies / Tocopherols - blood / Triglycerides - blood / vitamin A / Vitamin A - blood / Vitamins / Vitamins - blood