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Effects of Nasal Corticosteroids on Boosts of Systemic Allergen-Specific IgE Production Induced by Nasal Allergen Exposure
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Effects of Nasal Corticosteroids on Boosts of Systemic Allergen-Specific IgE Production Induced by Nasal Allergen Exposure
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Journal Article
Effects of Nasal Corticosteroids on Boosts of Systemic Allergen-Specific IgE Production Induced by Nasal Allergen Exposure
2015
Overview
Allergen exposure via the respiratory tract and in particular via the nasal mucosa boosts systemic allergen-specific IgE production. Intranasal corticosteroids (INCS) represent a first line treatment of allergic rhinitis but their effects on this boost of allergen-specific IgE production are unclear.
Here we aimed to determine in a double-blind, placebo-controlled study whether therapeutic doses of an INCS preparation, i.e., nasal fluticasone propionate, have effects on boosts of allergen-specific IgE following nasal allergen exposure.
Subjects (n = 48) suffering from grass and birch pollen allergy were treated with daily fluticasone propionate or placebo nasal spray for four weeks. After two weeks of treatment, subjects underwent nasal provocation with either birch pollen allergen Bet v 1 or grass pollen allergen Phl p 5. Bet v 1 and Phl p 5-specific IgE, IgG1-4, IgM and IgA levels were measured in serum samples obtained at the time of provocation and one, two, four, six and eight weeks thereafter.
Nasal allergen provocation induced a median increase to 141.1% of serum IgE levels to allergens used for provocation but not to control allergens 4 weeks after provocation. There were no significant differences regarding the boosts of allergen-specific IgE between INCS- and placebo-treated subjects.
In conclusion, the application of fluticasone propionate had no significant effects on the boosts of systemic allergen-specific IgE production following nasal allergen exposure.
http://clinicaltrials.gov/NCT00755066.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Adrenal Cortex Hormones - administration & dosage
/ Adrenal Cortex Hormones - adverse effects
/ Adrenal Cortex Hormones - immunology
/ Adrenal Cortex Hormones - therapeutic use
/ Adult
/ Analysis
/ Anti-Allergic Agents - administration & dosage
/ Anti-Allergic Agents - adverse effects
/ Anti-Allergic Agents - immunology
/ Anti-Allergic Agents - therapeutic use
/ Antigens
/ Asthma
/ B cells
/ Exposure
/ Female
/ Fluticasone - administration & dosage
/ Fluticasone - adverse effects
/ Fluticasone - therapeutic use
/ Grasses
/ Humans
/ Male
/ Mucosa
/ Nose
/ Pollen
/ Rhinitis
/ Rhinitis, Allergic - drug therapy
/ Rhinitis, Allergic - immunology
/ Studies
