Journal Article

Tobacco Smoking and Tuberculosis among Men Living with HIV in Johannesburg, South Africa: A Case-Control Study

Martinson, Neil, Samet, Jonathan M., Moloney, Rachael M., Golub, Jonathan E., Msandiwa, Regina, Mashabela, Mondiwana, Bronner Murrison, Liza

2016

Overview

Although there is ample evidence that smoking increases the risk of tuberculosis (TB), the magnitude of impact on TB risk among HIV-infected persons is poorly described. Given that a high proportion of patients with TB are co-infected with HIV in South Africa, the risks arising from the intersection of smoking, TB, and HIV/AIDS have key relevance for tobacco control policies. To evaluate the association of pulmonary tuberculosis (PTB) with current tobacco smoking among men with HIV in South Africa. Case-control study of antiretroviral therapy naïve men with confirmed HIV-infection in Johannesburg. Cases had laboratory-confirmed PTB and controls had no evidence of active TB. Participants were interviewed to collect detailed smoking histories. We enrolled 146 men diagnosed with PTB and 133 controls. Overall, 33% of participants were currently smoking, defined as smoking a cigarette within 2 months (34% cases vs. 32% controls, p = 0.27). Median CD4 count was lower (60 vs. 81 cells/mm3, P = 0.03) and median viral load was higher (173 vs. 67 copies/ul per thousand, P<0.001) among cases versus controls. In adjusted analyses, current smoking tripled the odds of PTB (aOR 3.2; 95%CI: 1.3-7.9, P = 0.01) and former smoking nearly doubled the odds of PTB (aOR 1.8; 95%CI 0.8-4.4, P = 0.18) compared to never smoking. Males with HIV that smoke are at greater odds for developing PTB than non-smokers. Extensive smoking cessation programs are needed to reduce odds of TB and promote health among adults living with HIV.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Acquired immune deficiency syndrome / Adult / Adults / AIDS / Alcohol / Alcohol use / Analysis / Antiretroviral agents / Antiretroviral therapy / Biology and Life Sciences / Case studies / Case-Control Studies / CD4 antigen / Coinfection - epidemiology / Drug addiction / Epidemiology / Health aspects / Health care / Health promotion / Health risks / HIV / HIV Infections - complications / HIV Infections - epidemiology / HIV patients / HIV-1 / Human immunodeficiency virus / Humans / Lentivirus / Male / Males / Medicine and Health Sciences / Men / Mens health / Middle Aged / Mycobacterium / Mycobacterium tuberculosis / People and places / Population / Prevalence / Preventive medicine / Public health / Pulmonary tuberculosis / Retroviridae / Risk Factors / Smoke / Smoking / Smoking - epidemiology / Socioeconomic Factors / South Africa - epidemiology / Studies / Surveys and Questionnaires / Tobacco / Tobacco smoking / Tuberculosis / Tuberculosis, Pulmonary - complications / Tuberculosis, Pulmonary - epidemiology