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YY1 Is Required for Germinal Center B Cell Development
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Journal Article
YY1 Is Required for Germinal Center B Cell Development
2016
Overview
YY1 has been implicated as a master regulator of germinal center B cell development as YY1 binding sites are frequently present in promoters of germinal center-expressed genes. YY1 is known to be important for other stages of B cell development including the pro-B and pre-B cells stages. To determine if YY1 plays a critical role in germinal center development, we evaluated YY1 expression during B cell development, and used a YY1 conditional knock-out approach for deletion of YY1 in germinal center B cells (CRE driven by the immunoglobulin heavy chain γ1 switch region promoter; γ1-CRE). We found that YY1 is most highly expressed in germinal center B cells and is increased 3 fold in splenic B cells activated by treatment with anti-IgM and anti-CD40. In addition, deletion of the yy1 gene by action of γ1-CRE recombinase resulted in significant loss of GC cells in both un-immunized and immunized contexts with corresponding loss of serum IgG1. Our results show a crucial role for YY1 in the germinal center reaction.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Animals
/ Antibodies, Anti-Idiotypic - pharmacology
/ Antibodies, Monoclonal - pharmacology
/ B cells
/ DNA
/ Germinal Center - immunology
/ Immunoglobulin Heavy Chains - genetics
/ Immunoglobulin Heavy Chains - metabolism
/ Lymphoma
/ Medicine and Health Sciences
/ Mice
/ Precursor Cells, B-Lymphoid - cytology
/ Precursor Cells, B-Lymphoid - immunology
/ Proteins
/ Research and Analysis Methods
/ Spleen
/ YY1 Transcription Factor - deficiency
