Journal Article

Is prehospital endobronchial intubation a risk factor for subsequent ventilator associated pneumonia? A retrospective analysis

Vignon, Philippe, Hernandez Padilla, Ana Catalina, Cailloce, Dominique, François, Bruno, Barraud, Olivier, Trampont, Timothée, Lafon, Thomas, Daix, Thomas, Dalmay, François

2019

Overview

More than half of patients under mechanical ventilation in the intensive care unit (ICU) are field-intubated, which is a known risk factor for ventilator associated pneumonia (VAP). We assessed whether field endobronchial intubation (EBI) is associated with the development of subsequent VAP during the ICU stay. This retrospective, nested case-control study was conducted in a cohort of field-intubated patients admitted to an ICU of a teaching hospital during a three-year period. Cases were defined as field-intubated patients with EBI and controls corresponded to field-intubated patients with proper position of the tracheal tube on admission chest X-ray. Primary endpoint was the development of early VAP. Secondary endpoints included the development of early ventilator associated tracheo-bronchitis, late VAP, duration of mechanical ventilation, length of stay and mortality in the ICU. A total of 145 patients were studied (mean age: 54 ± 19 years; men: 74%). Reasons for field intubation were predominantly multiple trauma (49%) and cardiorespiratory arrest (38%). EBI was identified in 33 patients (23%). Fifty-three patients (37%) developed early or late VAP. EBI after field intubation was associated with a nearly two-fold increase of early VAP, though not statistically significant (30% vs. 17%: p = 0.09). No statistically significant difference was found regarding secondary outcomes. The present study suggests that inadvertent prehospital EBI could be associated with a higher incidence of early-onset VAP. Larger studies are required to confirm this hypothesis. Whether strategies aimed at decreasing the incidence and duration of EBI could reduce the incidence of subsequent VAP remains to be determined.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Adult / Age / Aged / Antibiotics / Biology and Life Sciences / Bronchitis / Cardiac arrest / Care and treatment / Case-Control Studies / Complications and side effects / Engineering and Technology / Female / Health aspects / Human health and pathology / Humans / Incidence / Infectious diseases / Intensive Care Units / Intubation / Intubation, Intratracheal - adverse effects / Life Sciences / Male / Mechanical ventilation / Medical records / Medicine and Health Sciences / Middle Aged / Mortality / Patients / Pneumonia / Pneumonia, Ventilator-Associated - etiology / Pulmonology and respiratory tract / Respiration, Artificial - adverse effects / Retrospective Studies / Risk analysis / Risk Factors / Significance / Statistical analysis / Statistical significance / Surveys / Systematic review / Trauma / Ventilation / Ventilator-associated pneumonia / Ventilators