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Kappa B--Specific DNA Binding Proteins: Role in the Regulation of Human Interleukin-2 Gene Expression
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Kappa B--Specific DNA Binding Proteins: Role in the Regulation of Human Interleukin-2 Gene Expression
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Journal Article
Kappa B--Specific DNA Binding Proteins: Role in the Regulation of Human Interleukin-2 Gene Expression
1989
Overview
Transcriptional activation of the human interleukin-2 (IL-2) gene, like induction of the IL-2 receptor $\\alpha $ (IL-2R$\\alpha $) gene and the type 1 human immunodeficiency virus (HIV-1), is shown to be modulated by a $\\kappa $B-like enhancer element. Mutation of a $\\kappa $B core sequence identified in the IL-2 promoter (-206 to -195) partially inhibits both mitogen- and HTLV-I Tax-mediated activation of this transcription unit and blocks the specific binding of two inducible cellular factors. These $\\kappa $B-specific proteins (80 to 90 and 50 to 55 kilodaltons) similarly interact with the functional $\\kappa $B enhancer present in the IL-2R$\\alpha $ promoter. These data suggest that these $\\kappa $B-specific proteins have a role in the coordinate regulation of this growth factor-growth factor receptor gene system that controls T cell proliferation.
Publisher
The American Association for the Advancement of Science,American Association for the Advancement of Science
Subject
/ Biological and medical sciences
/ DNA
/ DNA-Binding Proteins - metabolism
/ Fundamental and applied biological sciences. Psychology
/ Gels
/ Genetics
/ HIV 1
/ HTLV-I Antigens - pharmacology
/ Humans
/ Immunoglobulin kappa-Chains - genetics
/ Molecular and cellular biology
/ Mutation
/ Phytohemagglutinins - pharmacology
/ Plasmids
/ Proteins
/ RNA, Messenger - biosynthesis
/ T cells
/ Tetradecanoylphorbol Acetate - pharmacology
