Asset Details
Do you wish to reserve the book?
Human Herpesvirus 6A Partially Suppresses Functional Properties of DC without Viral Replication
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Human Herpesvirus 6A Partially Suppresses Functional Properties of DC without Viral Replication
Do you wish to request the book?
Human Herpesvirus 6A Partially Suppresses Functional Properties of DC without Viral Replication
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Human Herpesvirus 6A Partially Suppresses Functional Properties of DC without Viral Replication
2013
Overview
Human herpesvirus 6A (HHV-6A) is a common virus with a worldwide distribution that has been associated with multiple sclerosis. Whether HHV-6A can replicate in dendritic cells (DC) and how the infection might modulate the functional properties of the cell are currently not well known and need further investigations. Here, we show that a non-productive infection of HHV-6A in DC leads to the up-regulation of HLA-ABC, via autocrine IFN-α signaling, as well as the up-regulation of HLA-DR and CD86. However, HHV-6A exposure reduces IL-8 secretion by DC and their capacity to stimulate allogenic T cell proliferation. The ability to suppress DC functions important for activation of innate and adaptive immune responses might be one successful strategy by which HHV-6A avoids the induction of appropriate host defense mechanisms, and thus facilitating persistent infection.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Analysis
/ B cells
/ Biology
/ CD4-Positive T-Lymphocytes - immunology
/ CD8-Positive T-Lymphocytes - immunology
/ Dendritic Cells - immunology
/ Herpesvirus 6, Human - immunology
/ Herpesvirus 6, Human - pathogenicity
/ Herpesvirus 6, Human - physiology
/ Histocompatibility antigen HLA
/ Host-Pathogen Interactions - immunology
/ Humans
/ Inflammation Mediators - metabolism
/ Interferon-alpha - metabolism
/ Interleukin-4 - biosynthesis
/ Medicine
/ R&D
/ T cells
/ Viruses
