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Developmental regulation of regenerative potential in Drosophila by ecdysone through a bistable loop of ZBTB transcription factors
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Developmental regulation of regenerative potential in Drosophila by ecdysone through a bistable loop of ZBTB transcription factors
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Developmental regulation of regenerative potential in Drosophila by ecdysone through a bistable loop of ZBTB transcription factors
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Journal Article
Developmental regulation of regenerative potential in Drosophila by ecdysone through a bistable loop of ZBTB transcription factors
2019
Overview
In many organisms, the regenerative capacity of tissues progressively decreases as development progresses. However, the developmental mechanisms that restrict regenerative potential remain unclear. In Drosophila, wing imaginal discs become unable to regenerate upon damage during the third larval stage (L3). Here, we show that production of ecdysone after larvae reach their critical weight (CW) terminates the window of regenerative potential by acting on a bistable loop composed of two antagonistic Broad-complex/Tramtrack/Bric-à-brac Zinc-finger (ZBTB) genes: chinmo and broad (br). Around mid L3, ecdysone signaling silences chinmo and activates br to switch wing epithelial progenitors from a default self-renewing to a differentiation-prone state. Before mid L3, Chinmo promotes a strong regenerative response upon tissue damage. After mid L3, Br installs a nonpermissive state that represses regeneration. Transient down-regulation of ecdysone signaling or Br in late L3 larvae enhances chinmo expression in damaged cells that regain the capacity to regenerate. This work unveils a mechanism that ties the self-renewing and regenerative potential of epithelial progenitors to developmental progression.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Animals
/ Control
/ Drosophila melanogaster - cytology
/ Drosophila melanogaster - genetics
/ Drosophila melanogaster - growth & development
/ Drosophila melanogaster - metabolism
/ Drosophila Proteins - genetics
/ Drosophila Proteins - metabolism
/ Ecdysone
/ Epithelial Cells - metabolism
/ Gene Expression Regulation, Developmental
/ Genes
/ Insects
/ Kinases
/ Larva - growth & development
/ Larvae
/ Nerve Tissue Proteins - genetics
/ Nerve Tissue Proteins - metabolism
/ Proteins
/ Research and Analysis Methods
/ Transcription Factors - genetics
/ Transcription Factors - metabolism
/ Zinc
