Journal Article

Abnormalities of intrinsic regional brain activity in first-episode and chronic schizophrenia: a meta-analysis of resting-state functional MRI

Wang, Junjing, Huang, Huiyuan, Huang, Li, Gong, Jiaying, Luo, Xiaomei, Wang, Ying, Huang, Ruiwang, Chen, Guanmao

2020

Overview

Resting-state functional MRI (fMRI) studies have provided much evidence for abnormal intrinsic brain activity in schizophrenia, but results have been inconsistent. We conducted a meta-analysis of whole-brain, resting-state fMRI studies that explored differences in amplitude of low-frequency fluctuation (ALFF) between people with schizophrenia (including first episode and chronic) and healthy controls. A systematic literature search identified 24 studies comparing a total of 1249 people with schizophrenia and 1179 healthy controls. Overall, patients with schizophrenia displayed decreased ALFF in the bilateral postcentral gyrus, bilateral precuneus, left inferior parietal gyri and right occipital lobe, and increased ALFF in the right putamen, right inferior frontal gyrus, left inferior temporal gyrus and right anterior cingulate cortex. In the subgroup analysis, patients with first-episode schizophrenia demonstrated decreased ALFF in the bilateral inferior parietal gyri, right precuneus and left medial prefrontal cortex, and increased ALFF in the bilateral putamen and bilateral occipital gyrus. Patients with chronic schizophrenia showed decreased ALFF in the bilateral postcentral gyrus, left precuneus and right occipital gyrus, and increased ALFF in the bilateral inferior frontal gyri, bilateral superior frontal gyrus, left amygdala, left inferior temporal gyrus, right anterior cingulate cortex and left insula. The small sample size of our subgroup analysis, predominantly Asian samples, processing steps and publication bias could have limited the accuracy of the results. Our comprehensive meta-analysis suggests that findings of aberrant regional intrinsic brain activity during the initial stages of schizophrenia, and much more widespread damage with the progression of disease, may contribute to our understanding of the progressive pathophysiology of schizophrenia.

• Publisher: Canadian Medical Association,NRC Research Press,Joule Inc,Cooperative Education Association
• Subject: Adult / Amygdala / Brain / Brain mapping / Brain research / Cerebral Cortex - diagnostic imaging / Cerebral Cortex - physiopathology / Cortex (cingulate) / Cortex (parietal) / Data analysis / Datasets / Diagnostic imaging / Frontal gyrus / Functional magnetic resonance imaging / Functional Neuroimaging / Humans / Illnesses / Magnetic Resonance Imaging / Medical imaging / Mental disorders / Meta-analysis / Middle Aged / Occipital lobe / Patients / Postcentral gyrus / Prefrontal cortex / Psychiatric/Mental Health / Putamen / Regression analysis / Research Paper / Schizophrenia / Schizophrenia - diagnostic imaging / Schizophrenia - physiopathology / Sensitivity analysis / Software / Systematic review / Temporal gyrus / Temporal lobe / Young Adult