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The major genetic risk factor for severe COVID-19 is inherited from Neanderthals
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Journal Article
The major genetic risk factor for severe COVID-19 is inherited from Neanderthals
2020
Overview
A recent genetic association study
1
identified a gene cluster on chromosome 3 as a risk locus for respiratory failure after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A separate study (COVID-19 Host Genetics Initiative)
2
comprising 3,199 hospitalized patients with coronavirus disease 2019 (COVID-19) and control individuals showed that this cluster is the major genetic risk factor for severe symptoms after SARS-CoV-2 infection and hospitalization. Here we show that the risk is conferred by a genomic segment of around 50 kilobases in size that is inherited from Neanderthals and is carried by around 50% of people in south Asia and around 16% of people in Europe.
Risk of severe COVID-19 is conferred by a genomic segment that is inherited from Neanderthals and is carried by around 50% and 16% of people in south Asia and Europe, respectively.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 45/43
/ Animals
/ Chromosomes, Human, Pair 3 - genetics
/ COVID-19
/ Genetic Predisposition to Disease
/ Genetic Variation - genetics
/ Genetics
/ Genome-Wide Association Study
/ Genomes
/ Humanities and Social Sciences
/ Humans
/ Linkage Disequilibrium - genetics
/ Science
/ Severe Acute Respiratory Syndrome - complications
/ Severe Acute Respiratory Syndrome - genetics
/ Severe Acute Respiratory Syndrome - physiopathology
