Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

high-quality catalog of the Drosophila melanogaster proteome

by Baetschmann, H , Loevenich, S , Panse, C , Deutsch, E.W , Brunner, E , Ahrens, C.H , Lichtenberg, U. de , Rinner, O , Potthast, F , Mohanty, S

in Agriculture / Amino Acid Sequence / Animals / Biochemistry / Bioinformatics / Biomedical Engineering/Biotechnology / Biomedicine / Biotechnology / chemistry / Data collection / Databases, Protein / Drosophila / Drosophila melanogaster / Drosophila melanogaster - chemistry / Drosophila melanogaster - genetics / Drosophila Proteins / Drosophila Proteins - chemistry / Drosophila Proteins - genetics / Fractionation / Genes / genetics / Genomes / Genomics / insect proteins / Insects / Life Sciences / Molecular Sequence Data / Peptides / Proteins / proteome / Proteome - chemistry / Proteome - genetics / Proteomics / Statistical analysis

2007

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

high-quality catalog of the Drosophila melanogaster proteome

by Baetschmann, H , Loevenich, S , Panse, C , Deutsch, E.W , Brunner, E , Ahrens, C.H , Lichtenberg, U. de , Rinner, O , Potthast, F , Mohanty, S

2007

Confirm

Do you wish to request the book?

high-quality catalog of the Drosophila melanogaster proteome

by Baetschmann, H , Loevenich, S , Panse, C , Deutsch, E.W , Brunner, E , Ahrens, C.H , Lichtenberg, U. de , Rinner, O , Potthast, F , Mohanty, S

2007

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

high-quality catalog of the Drosophila melanogaster proteome

Baetschmann, H,

Loevenich, S,

Panse, C,

Deutsch, E.W,

Brunner, E,

Ahrens, C.H,

Lichtenberg, U. de,

Rinner, O,

Potthast, F,

Mohanty, S

2007

Overview

Understanding how proteins and their complex interaction networks convert the genomic information into a dynamic living organism is a fundamental challenge in biological sciences. As an important step towards understanding the systems biology of a complex eukaryote, we cataloged 63% of the predicted Drosophila melanogaster proteome by detecting 9,124 proteins from 498,000 redundant and 72,281 distinct peptide identifications. This unprecedented high proteome coverage for a complex eukaryote was achieved by combining sample diversity, multidimensional biochemical fractionation and analysis-driven experimentation feedback loops, whereby data collection is guided by statistical analysis of prior data. We show that high-quality proteomics data provide crucial information to amend genome annotation and to confirm many predicted gene models. We also present experimentally identified proteotypic peptides matching ∼50% of D. melanogaster gene models. This library of proteotypic peptides should enable fast, targeted and quantitative proteomic studies to elucidate the systems biology of this model organism.

Share this book

Add to My Shelf

Publisher

Nature Publishing Group UK,Nature Publishing Group

Subject

Agriculture

/ Amino Acid Sequence

/ Animals

/ Biochemistry

/ Bioinformatics

/ Biomedical Engineering/Biotechnology

/ Biomedicine