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Auxin inhibits endocytosis and promotes its own efflux from cells
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Journal Article
Auxin inhibits endocytosis and promotes its own efflux from cells
2005
Overview
One of the mechanisms by which signalling molecules regulate cellular behaviour is modulating subcellular protein translocation. This mode of regulation is often based on specialized vesicle trafficking, termed constitutive cycling, which consists of repeated internalization and recycling of proteins to and from the plasma membrane. No such mechanism of hormone action has been shown in plants although several proteins, including the PIN auxin efflux facilitators, exhibit constitutive cycling. Here we show that a major regulator of plant development, auxin, inhibits endocytosis. This effect is specific to biologically active auxins and requires activity of the Calossin-like protein BIG. By inhibiting the internalization step of PIN constitutive cycling, auxin increases levels of PINs at the plasma membrane. Concomitantly, auxin promotes its own efflux from cells by a vesicle-trafficking-dependent mechanism. Furthermore, asymmetric auxin translocation during gravitropism is correlated with decreased PIN internalization. Our data imply a previously undescribed mode of plant hormone action: by modulating PIN protein trafficking, auxin regulates PIN abundance and activity at the cell surface, providing a mechanism for the feedback regulation of auxin transport.
Publisher
Nature Publishing Group UK,Nature Publishing,Nature Publishing Group
Subject
/ Arabidopsis - growth & development
/ Arabidopsis Proteins - metabolism
/ auxins
/ Biological and medical sciences
/ Biological Transport - drug effects
/ Cell Membrane - drug effects
/ Cells
/ Fundamental and applied biological sciences. Psychology
/ Hormones
/ Humanities and Social Sciences
/ Indoleacetic Acids - metabolism
/ Indoleacetic Acids - pharmacology
/ letter
/ Plant physiology and development
/ Plant Roots - growth & development
/ Proteins
/ Science
