Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

The draft genome sequence of the ferret (Mustela putorius furo) facilitates study of human respiratory disease

by Aken, Bronwen , Peng, Xinxia , Turner-Maier, Jason , Lara, Marcia , Tyler, Scott R , Chang, Jean , Law, G Lynn , Kelly, Sara M , Hourlier, Thibaut , Siepel, Adam , Young, Sarah , Gori, Kevin , Tumpey, Terrence M , Johnson, Jeremy , Berlin, Aaron M , Swofford, Ross , Sun, Xingshen , Alföldi, Jessica , Eisfeld, Amie J , Skunca, Nives , Birren, Bruce W , Dessimoz, Christophe , Gasper, David J , Wisely, Samantha M , Katze, Michael G , Engelhardt, John F , Thomas, Matthew J , Di Palma, Federica , Suresh, M , Kawaoka, Yoshihiro , Hatta, Masato , Palermo, Robert E , Russell, Pamela , Searle, Steve , Lindblad-Toh, Kerstin , Tisoncik-Go, Jennifer , Brawand, David , Yi, Yaling

in 38/61 / 38/91 / 45/23 / 631/114/2785 / 631/208/191/2018 / 631/326/596/2553 / 631/61/212/2019 / Agriculture / Animal models / Animal models in research / Animals / Base Sequence / Bioinformatics / Biomedical Engineering/Biotechnology / Biomedicine / Biotechnology / Chromosome Mapping / Disease Models, Animal / DNA sequencing / Domestic animals / Ferrets / Ferrets - genetics / Genetic aspects / Genetic research / Genome / Genomes / High-Throughput Nucleotide Sequencing / Humans / Infants / Influenza virus / Influenza, Human - genetics / Influenza, Human - transmission / Influenza, Human - virology / letter / Life Sciences / Mammals / Methods / Molecular Sequence Annotation / Molecular Sequence Data / Mustela putorius furo / Nucleotide sequencing / Orthomyxoviridae - genetics / Orthomyxoviridae - pathogenicity / Pandemics / Respiratory diseases / Respiratory tract diseases / Sequence Analysis, DNA

2014

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

The draft genome sequence of the ferret (Mustela putorius furo) facilitates study of human respiratory disease

2014

Confirm

Do you wish to request the book?

The draft genome sequence of the ferret (Mustela putorius furo) facilitates study of human respiratory disease

2014

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

The draft genome sequence of the ferret (Mustela putorius furo) facilitates study of human respiratory disease

Aken, Bronwen,

Peng, Xinxia,

Turner-Maier, Jason,

Lara, Marcia,

Tyler, Scott R,

Chang, Jean,

Law, G Lynn,

Kelly, Sara M,

Hourlier, Thibaut,

Siepel, Adam,

Young, Sarah,

Gori, Kevin,

Tumpey, Terrence M,

Johnson, Jeremy,

Berlin, Aaron M,

Swofford, Ross,

Sun, Xingshen,

Alföldi, Jessica,

Eisfeld, Amie J,

Skunca, Nives,

Birren, Bruce W,

Dessimoz, Christophe,

Gasper, David J,

Wisely, Samantha M,

Katze, Michael G,

Engelhardt, John F,

Thomas, Matthew J,

Di Palma, Federica,

Suresh, M,

Kawaoka, Yoshihiro,

Hatta, Masato,

Palermo, Robert E,

Russell, Pamela,

Searle, Steve,

Lindblad-Toh, Kerstin,

Tisoncik-Go, Jennifer,

Brawand, David,

Yi, Yaling

2014

Overview

The genome sequence of the ferret, a model of human respiratory disease, enables research on influenza and cystic fibrosis. The domestic ferret ( Mustela putorius furo ) is an important animal model for multiple human respiratory diseases. It is considered the 'gold standard' for modeling human influenza virus infection and transmission 1 , 2 , 3 , 4 . Here we describe the 2.41 Gb draft genome assembly of the domestic ferret, constituting 2.28 Gb of sequence plus gaps. We annotated 19,910 protein-coding genes on this assembly using RNA-seq data from 21 ferret tissues. We characterized the ferret host response to two influenza virus infections by RNA-seq analysis of 42 ferret samples from influenza time-course data and showed distinct signatures in ferret trachea and lung tissues specific to 1918 or 2009 human pandemic influenza virus infections. Using microarray data from 16 ferret samples reflecting cystic fibrosis disease progression, we showed that transcriptional changes in the CFTR-knockout ferret lung reflect pathways of early disease that cannot be readily studied in human infants with cystic fibrosis disease.

Share this book

Add to My Shelf

Publisher

Nature Publishing Group US,Nature Publishing Group

Subject

38/61

/ 38/91

/ 45/23