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Perturbed human sub-networks by Fusobacterium nucleatum candidate virulence proteins
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Perturbed human sub-networks by Fusobacterium nucleatum candidate virulence proteins
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Journal Article
Perturbed human sub-networks by Fusobacterium nucleatum candidate virulence proteins
2017
Overview
Background
Fusobacterium nucleatum
is a gram-negative anaerobic species residing in the oral cavity and implicated in several inflammatory processes in the human body. Although
F. nucleatum
abundance is increased in inflammatory bowel disease subjects and is prevalent in colorectal cancer patients, the causal role of the bacterium in gastrointestinal disorders and the mechanistic details of host cell functions subversion are not fully understood.
Results
We devised a computational strategy to identify putative secreted
F. nucleatum
proteins (
Fuso
Secretome) and to infer their interactions with human proteins based on the presence of host molecular mimicry elements
. Fuso
Secretome proteins share similar features with known bacterial virulence factors thereby highlighting their pathogenic potential. We show that they interact with human proteins that participate in infection-related cellular processes and localize in established cellular districts of the host–pathogen interface. Our network-based analysis identified 31 functional modules in the human interactome preferentially targeted by 138
Fuso
Secretome proteins, among which we selected 26 as main candidate virulence proteins, representing both putative and known virulence proteins. Finally, six of the preferentially targeted functional modules are implicated in the onset and progression of inflammatory bowel diseases and colorectal cancer.
Conclusions
Overall, our computational analysis identified candidate virulence proteins potentially involved in the
F. nucleatum
—human cross-talk in the context of gastrointestinal diseases.
Publisher
BioMed Central,BioMed Central Ltd,BMC
Subject
Bacterial Proteins - isolation & purification
/ Bacterial Proteins - metabolism
/ Bacterial Proteins - secretion
/ Biomedical and Life Sciences
/ Colorectal Neoplasms - microbiology
/ Colorectal Neoplasms - physiopathology
/ Female
/ Fusobacterium Infections - microbiology
/ Fusobacterium Infections - physiopathology
/ Fusobacterium nucleatum - chemistry
/ Fusobacterium nucleatum - pathogenicity
/ Host-Pathogen Interactions - genetics
/ Humans
/ Inflammatory Bowel Diseases - microbiology
/ Inflammatory Bowel Diseases - physiopathology
/ Male
/ Microbial Genetics and Genomics
/ Proteins
/ Signal Transduction - genetics
/ Virology
