Asset Details
Do you wish to reserve the book?
SUPERGNOVA: local genetic correlation analysis reveals heterogeneous etiologic sharing of complex traits
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
SUPERGNOVA: local genetic correlation analysis reveals heterogeneous etiologic sharing of complex traits
Do you wish to request the book?
SUPERGNOVA: local genetic correlation analysis reveals heterogeneous etiologic sharing of complex traits
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
SUPERGNOVA: local genetic correlation analysis reveals heterogeneous etiologic sharing of complex traits
2021
Overview
Local genetic correlation quantifies the genetic similarity of complex traits in specific genomic regions. However, accurate estimation of local genetic correlation remains challenging, due to linkage disequilibrium in local genomic regions and sample overlap across studies. We introduce SUPERGNOVA, a statistical framework to estimate local genetic correlations using summary statistics from genome-wide association studies. We demonstrate that SUPERGNOVA outperforms existing methods through simulations and analyses of 30 complex traits. In particular, we show that the positive yet paradoxical genetic correlation between autism spectrum disorder and cognitive performance could be explained by two etiologically distinct genetic signatures with bidirectional local genetic correlations.
Publisher
BioMed Central,Springer Nature B.V,BMC
Subject
/ Autism
/ Autism Spectrum Disorder - genetics
/ Bias
/ Biomedical and Life Sciences
/ etiology
/ Genetic Predisposition to Disease
/ Genetics
/ genome
/ Genome-wide association studies
/ Genome-Wide Association Study
/ Genomes
/ Genomics
/ GWAS
/ Humans
/ Method
/ Microbial Genetics and Genomics
/ Multifactorial Inheritance - genetics
/ Power
/ Quantitative Trait, Heritable
/ Software
