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High-throughput cellular microarray platforms: applications in drug discovery, toxicology and stem cell research
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High-throughput cellular microarray platforms: applications in drug discovery, toxicology and stem cell research
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Journal Article
High-throughput cellular microarray platforms: applications in drug discovery, toxicology and stem cell research
2009
Overview
Cellular microarrays are powerful experimental tools for high-throughput screening of large numbers of test samples. Miniaturization increases assay throughput while reducing reagent consumption and the number of cells required, making these systems attractive for a wide range of assays in drug discovery, toxicology, stem cell research and potentially therapy. Here, we provide an overview of the emerging technologies that can be used to generate cellular microarrays, and we highlight recent significant advances in the field. This emerging and multidisciplinary approach offers new opportunities for the design and control of stem cells in tissue engineering and cellular therapies and promises to expedite drug discovery in the biotechnology and pharmaceutical industries.
Publisher
Elsevier Ltd,[London]: Elsevier Science,Cell Press,Elsevier Limited
Subject
/ Biological and medical sciences
/ Cells
/ drugs
/ Fundamental and applied biological sciences. Psychology
/ Humans
/ Microfluidic Analytical Techniques
/ Oligonucleotide Array Sequence Analysis
/ R&D
/ Tissue Array Analysis - instrumentation
/ Tissue Array Analysis - methods
