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Costs of Tuberculosis at 3 Treatment Centers, Canada, 2010–2016

by Rea, Elizabeth , Sabur, Natasha F. , Chiang, Leslie Y. , Oxlade, Olivia , Schwartzman, Kevin , Johnston, James C. , Jamieson, Frances , Sander, Beate , Uppal, Aashna , Brode, Sarah K. , Khadawardi, Hadeel , Mah, Henry K.-H. , Campbell, Jonathon R. , Romanowski, Kamila , Nsengiyumva, Placide , Rasberry, Hayden

in Antimicrobial agents / antimicrobial resistance / Antitubercular Agents - therapeutic use / bacteria / bacterial infections / Canada - epidemiology / Care and treatment / cost assessment / Cost estimates / Costs of Tuberculosis at 3 Treatment Centers, Canada, 2010–2016 / Decision making / Diagnostic tests / Drug resistance / Economic aspects / Health surveillance / Hospitalization / Humans / Infections / Isoniazid - therapeutic use / Latent Tuberculosis - drug therapy / Medical care, Cost of / Mycobacterium tuberculosis / Public health / respiratory infections / Retrospective Studies / Statistics / Tuberculosis / Tuberculosis - drug therapy / Tuberculosis - epidemiology / tuberculosis and other mycobacteria / Tuberculosis, Multidrug-Resistant - drug therapy / Tuberculosis, Multidrug-Resistant - epidemiology

2022

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2022

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2022

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Journal Article

Costs of Tuberculosis at 3 Treatment Centers, Canada, 2010–2016

Rea, Elizabeth,

Sabur, Natasha F.,

Chiang, Leslie Y.,

Oxlade, Olivia,

Schwartzman, Kevin,

Johnston, James C.,

Jamieson, Frances,

Sander, Beate,

Uppal, Aashna,

Brode, Sarah K.,

Khadawardi, Hadeel,

Mah, Henry K.-H.,

Campbell, Jonathon R.,

Romanowski, Kamila,

Nsengiyumva, Placide,

Rasberry, Hayden

2022

Overview

We estimated costs of managing different forms of tuberculosis (TB) across Canada by conducting a retrospective chart review and cost assessment of patients treated for TB infection, drug-susceptible TB (DS TB), isoniazid-resistant TB, or multidrug-resistant TB (MDR TB) at 3 treatment centers. We included 90 patients each with TB infection and DS TB, 71 with isoniazid-resistant TB, and 62 with MDR TB. Median per-patient costs for TB infection (in 2020 Canadian dollars) were $804 (interquartile range [IQR] $587-$1,205), for DS TB $12,148 (IQR $4,388-$24,842), for isoniazid-resistant TB $19,319 (IQR $7,117-$41,318), and for MDR TB $119,014 (IQR $80,642-$164,015). Compared with costs for managing DS TB, costs were 11.1 (95% CI 9.1-14.3) times lower for TB infection, 1.7 (95% CI 1.3-2.1) times higher for isoniazid-resistant TB, and 8.1 (95% CI 6.1-10.6) times higher for MDR TB. Broadened TB infection treatment could avert high costs associated with managing TB disease.

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Publisher

U.S. National Center for Infectious Diseases,Centers for Disease Control and Prevention

Subject

Antimicrobial agents

/ antimicrobial resistance

/ Antitubercular Agents - therapeutic use

/ bacteria

/ bacterial infections

/ Canada - epidemiology

/ Care and treatment