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Correlates of Protection, Thresholds of Protection, and Immunobridging among Persons with SARS-CoV-2 Infection

by Fong, Youyi , Kent, Stephen J. , Subbarao, Kanta , Steain, Megan , Davenport, Miles P. , Schlub, Timothy E. , Cromer, Deborah , Triccas, James A. , Gilbert, Peter B. , Khoury, David S.

in 2019 novel coronavirus disease / Agreements / Antibodies / Antibodies, Neutralizing / Antibodies, Viral / Biotechnology industry / coronavirus disease / Coronaviruses / Correlates of Protection, Thresholds of Protection, and Immunobridging among Persons with SARS-CoV-2 Infection / COVID-19 / COVID-19 Vaccines / Health aspects / Humans / Immune response / Immunological research / Infection / Infections / Influenza vaccines / Measurement / Medical research / Medicine, Experimental / Pandemics / Pandemics - prevention & control / Pharmaceutical industry / Public health / SARS-CoV-2 / Severe acute respiratory syndrome coronavirus 2 / Spike Glycoprotein, Coronavirus / Viral antibodies / viruses

2023

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Correlates of Protection, Thresholds of Protection, and Immunobridging among Persons with SARS-CoV-2 Infection

by Fong, Youyi , Kent, Stephen J. , Subbarao, Kanta , Steain, Megan , Davenport, Miles P. , Schlub, Timothy E. , Cromer, Deborah , Triccas, James A. , Gilbert, Peter B. , Khoury, David S.

2023

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Correlates of Protection, Thresholds of Protection, and Immunobridging among Persons with SARS-CoV-2 Infection

by Fong, Youyi , Kent, Stephen J. , Subbarao, Kanta , Steain, Megan , Davenport, Miles P. , Schlub, Timothy E. , Cromer, Deborah , Triccas, James A. , Gilbert, Peter B. , Khoury, David S.

2023

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Journal Article

Correlates of Protection, Thresholds of Protection, and Immunobridging among Persons with SARS-CoV-2 Infection

Fong, Youyi,

Kent, Stephen J.,

Subbarao, Kanta,

Steain, Megan,

Davenport, Miles P.,

Schlub, Timothy E.,

Cromer, Deborah,

Triccas, James A.,

Gilbert, Peter B.,

Khoury, David S.

2023

Overview

Several studies have shown that neutralizing antibody levels correlate with immune protection from COVID-19 and have estimated the relationship between neutralizing antibodies and protection. However, results of these studies vary in terms of estimates of the level of neutralizing antibodies required for protection. By normalizing antibody titers, we found that study results converge on a consistent relationship between antibody levels and protection from COVID-19. This finding can be useful for planning future vaccine use, determining population immunity, and reducing the global effects of the COVID-19 pandemic.

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Publisher

U.S. National Center for Infectious Diseases,Centers for Disease Control and Prevention

Subject

2019 novel coronavirus disease

/ Agreements

/ Antibodies

/ Antibodies, Neutralizing

/ Antibodies, Viral

/ Biotechnology industry

/ coronavirus disease