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Correlation of SARS-CoV-2 Subgenomic RNA with Antigen Detection in Nasal Midturbinate Swab Specimens

by Levy, Joshua M. , Waggoner, Jesse J. , Lam, Wilbur A. , Elias-Marcellin, Roger , Immergluck, Katherine , Wood, Anna , Sullivan, Julie , O’Neal, Jared , Rogers, Beverly B. , Frediani, Jennifer K. , Babiker, Ahmed , Piantadosi, Anne , Schinazi, Raymond F. , Vos, Miriam B. , Gonzalez, Mark D. , Martin, Greg S. , Suessmith, Allie , Figueroa, Janet

in Antigens / coronavirus / coronavirus disease / Coronaviruses / Correlation of SARS-CoV-2 Subgenomic RNA with Antigen Detection in Nasal Midturbinate Swab Specimens / COVID-19 / COVID-19 diagnostic tests / Diagnostic Tests, Routine / Dispatch / Expedited / Humans / Immune system / Methods / Molecular diagnostic techniques / Nasopharynx / RNA / SARS-CoV-2 / Severe acute respiratory syndrome coronavirus 2 / Testing / Viral antigens / viruses

2021

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Correlation of SARS-CoV-2 Subgenomic RNA with Antigen Detection in Nasal Midturbinate Swab Specimens

2021

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Correlation of SARS-CoV-2 Subgenomic RNA with Antigen Detection in Nasal Midturbinate Swab Specimens

2021

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Journal Article

Correlation of SARS-CoV-2 Subgenomic RNA with Antigen Detection in Nasal Midturbinate Swab Specimens

Levy, Joshua M.,

Waggoner, Jesse J.,

Lam, Wilbur A.,

Elias-Marcellin, Roger,

Immergluck, Katherine,

Wood, Anna,

Sullivan, Julie,

O’Neal, Jared,

Rogers, Beverly B.,

Frediani, Jennifer K.,

Babiker, Ahmed,

Piantadosi, Anne,

Schinazi, Raymond F.,

Vos, Miriam B.,

Gonzalez, Mark D.,

Martin, Greg S.,

Suessmith, Allie,

Figueroa, Janet

2021

Overview

Among symptomatic outpatients, subgenomic RNA of severe acute respiratory syndrome coronavirus 2 in nasal midturbinate swab specimens was concordant with antigen detection but remained detectable in 13 (82.1%) of 16 nasopharyngeal swab specimens from antigen-negative persons. Subgenomic RNA in midturbinate swab specimens might be useful for routine diagnostics to identify active virus replication.

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Publisher

U.S. National Center for Infectious Diseases,Centers for Disease Control and Prevention

Subject

Antigens

/ coronavirus

/ coronavirus disease

/ Coronaviruses

/ Correlation of SARS-CoV-2 Subgenomic RNA with Antigen Detection in Nasal Midturbinate Swab Specimens

/ COVID-19

/ COVID-19 diagnostic tests