Asset Details
Do you wish to reserve the book?
Metabolite Profiling of Alzheimer's Disease Cerebrospinal Fluid
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Metabolite Profiling of Alzheimer's Disease Cerebrospinal Fluid
Do you wish to request the book?
Metabolite Profiling of Alzheimer's Disease Cerebrospinal Fluid
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Metabolite Profiling of Alzheimer's Disease Cerebrospinal Fluid
2012
Overview
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive loss of cognitive functions. Today the diagnosis of AD relies on clinical evaluations and is only late in the disease. Biomarkers for early detection of the underlying neuropathological changes are still lacking and the biochemical pathways leading to the disease are still not completely understood. The aim of this study was to identify the metabolic changes resulting from the disease phenotype by a thorough and systematic metabolite profiling approach. For this purpose CSF samples from 79 AD patients and 51 healthy controls were analyzed by gas and liquid chromatography-tandem mass spectrometry (GC-MS and LC-MS/MS) in conjunction with univariate and multivariate statistical analyses. In total 343 different analytes have been identified. Significant changes in the metabolite profile of AD patients compared to healthy controls have been identified. Increased cortisol levels seemed to be related to the progression of AD and have been detected in more severe forms of AD. Increased cysteine associated with decreased uridine was the best paired combination to identify light AD (MMSE>22) with specificity and sensitivity above 75%. In this group of patients, sensitivity and specificity above 80% were obtained for several combinations of three to five metabolites, including cortisol and various amino acids, in addition to cysteine and uridine.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Age
/ Aging
/ Alzheimer Disease - cerebrospinal fluid
/ Alzheimer Disease - diagnosis
/ Alzheimer Disease - metabolism
/ Cortisol
/ Cysteine
/ Cysteine - cerebrospinal fluid
/ Cystine
/ Dementia
/ Gas Chromatography-Mass Spectrometry
/ Hormones
/ Humans
/ Hydrocortisone - cerebrospinal fluid
/ Medicine
/ NMR
/ Patients
/ Plasma
/ Proteins
/ Uridine
