Asset Details
Do you wish to reserve the book?
Coronary collateralization shows sex and racial-ethnic differences in obstructive artery disease patients
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Coronary collateralization shows sex and racial-ethnic differences in obstructive artery disease patients
Do you wish to request the book?
Coronary collateralization shows sex and racial-ethnic differences in obstructive artery disease patients
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Coronary collateralization shows sex and racial-ethnic differences in obstructive artery disease patients
2017
Overview
Coronary collateral circulation protects cardiac tissues from myocardial infarction damage and decreases sudden cardiac death. So far, it is unclear how coronary collateralization varies by race-ethnicity groups and by sex.
We assessed 868 patients with obstructive CAD. Patients were assessed for collateral grades based on Rentrop grading system, as well as other covariates. DNA samples were genotyped using the Affymetrix 6.0 genotyping array. To evaluate genetic contributions to collaterals, we performed admixture mapping using logistic regression with estimated local and global ancestry.
Overall, 53% of participants had collaterals. We found difference between sex and racial-ethnic groups. Men had higher rates of collaterals than women (P-value = 0.000175). White Hispanics/Latinos showed overall higher rates of collaterals than African Americans and non-Hispanic Whites (59%, 50% and 48%, respectively, P-value = 0.017), and especially higher rates in grade 1 and grade 3 collateralization than the other two populations (P-value = 0.0257). Admixture mapping showed Native American ancestry was associated with the presence of collaterals at a region on chromosome 17 (chr17:35,243,142-41,251,931, β = 0.55, P-value = 0.000127). African ancestry also showed association with collaterals at a different region on chromosome 17 (chr17: 32,266,966-34,463,323, β = 0.38, P-value = 0.00072).
In our study, collateralization showed sex and racial-ethnic differences in obstructive CAD patients. We identified two regions on chromosome 17 that were likely to harbor genetic variations that influenced collateralization.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ African Americans - genetics
/ Aged
/ Atherosclerosis - epidemiology
/ Atherosclerosis - physiopathology
/ Collateral Circulation - genetics
/ Coronary Circulation - genetics
/ Coronary Circulation - physiology
/ Diabetes
/ DNA
/ European Continental Ancestry Group - genetics
/ Female
/ Genes
/ Genomes
/ Genomics
/ Genotype
/ Heart
/ Hispanic Americans - genetics
/ Humans
/ Indians, North American - genetics
/ Male
/ Mapping
/ Medicine
/ Medicine and Health Sciences
/ Myocardial Infarction - epidemiology
/ Myocardial Infarction - genetics
/ Myocardial Infarction - physiopathology
/ Patients
/ Quality
/ Sex
/ Studies
/ Tissues
