Journal Article

Relationship between G1287A of the NET Gene Polymorphisms and Brain Volume in Major Depressive Disorder: A Voxel-Based MRI Study

Yoshimura, Reiji, Kakeda, Shingo, Moriya, Junji, Abe, Osamu, Kishi, Taro, Ueda, Issei, Watanabe, Keita, Nakamura, Jun, Korogi, Yukunori, Iwata, Nakao, Ide, Satoru, Hori, Hikaru, Katsuki, Asuka

2016

Overview

Earlier studies implicated norepinephrine transporter (NET) gene (SLC6A2) polymorphisms in the etiology of major depressive disorder (MDD). Recently, two single nucleotide SLC6A2 polymorphisms, G1287A in exon 9 and T-182C in the promoter region, were found to be associated with MDD in different populations. We investigated the relationship between the brain volume and these two polymorphisms of the SLC6A2 in MDD patients. We obtained 3D high-resolution T1-weighted images of 30 first-episode MDD patients and 48 age- and sex-matched healthy subjects (HS). All were divided into 4 groups based on polymorphism of either the G1287A or the T-182C genotype. VBM analysis examined the effects of diagnosis, genotype, and genotype-diagnosis interactions. Diagnosis effects on the brain morphology were found in the left superior temporal cortex. No significant genotype effects were found in the T-182C and the G1287A. A significant genotype (G1287A)-diagnosis interaction was found in the left dorsolateral prefrontal cortex. No significant genotype (T-182C)-diagnosis interaction effects were observed in any brain region. In MDD patients there seems to be a relationship between the volume of the dorsolateral prefrontal cortex and polymorphism of the SLC6A2 G1287A gene.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Adult / Analysis / Antidepressants / Biology and Life Sciences / Brain / Brain - pathology / Brain-derived neurotrophic factor / Cortex (temporal) / Demography / Deoxyribonucleic acid / Depressive Disorder, Major - genetics / Diagnosis / DNA / Dopamine / Environmental health / Etiology / Female / Gene polymorphism / Genetic aspects / Genetic polymorphisms / Genetic Predisposition to Disease / Genotype & phenotype / Genotypes / Humans / Image resolution / Magnetic Resonance Imaging / Major depressive disorder / Male / Medical imaging / Medicine and Health Sciences / Mental depression / Norepinephrine / Norepinephrine Plasma Membrane Transport Proteins - genetics / Norepinephrine transporter / Organ Size / Patients / People and Places / Physical Sciences / Polymorphism / Polymorphism, Single Nucleotide - genetics / Prefrontal cortex / Psychiatry / Research and Analysis Methods / Risk factors / Studies / Temporal lobe