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Genetic epidemiology and Mendelian randomization for informing disease therapeutics: Conceptual and methodological challenges
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Genetic epidemiology and Mendelian randomization for informing disease therapeutics: Conceptual and methodological challenges
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Genetic epidemiology and Mendelian randomization for informing disease therapeutics: Conceptual and methodological challenges
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Journal Article
Genetic epidemiology and Mendelian randomization for informing disease therapeutics: Conceptual and methodological challenges
2017
Overview
The past decade has been proclaimed as a hugely successful era of gene discovery through the high yields of many genome-wide association studies (GWAS). However, much of the perceived benefit of such discoveries lies in the promise that the identification of genes that influence disease would directly translate into the identification of potential therapeutic targets, but this has yet to be realized at a level reflecting expectation. One reason for this, we suggest, is that GWAS, to date, have generally not focused on phenotypes that directly relate to the progression of disease and thus speak to disease treatment.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Computer and Information Sciences
/ Coronary Disease - epidemiology
/ Genetic Diseases, Inborn - epidemiology
/ Genetic Diseases, Inborn - genetics
/ Genetic Diseases, Inborn - pathology
/ Genetic Diseases, Inborn - therapy
/ Genetic Predisposition to Disease
/ Genome-wide association studies
/ Genome-Wide Association Study
/ Genomes
/ Humans
/ Medicine and Health Sciences
/ Mendelian Randomization Analysis
/ Methods
/ Review
/ Studies
