Journal Article

Levels of sP-selectin and hs-CRP Decrease with Dietary Intervention with Selenium and Coenzyme Q10 Combined: A Secondary Analysis of a Randomized Clinical Trial

Svensson, Erland, Alehagen, Urban, Johansson, Peter, Lindahl, Tomas L., Aaseth, Jan

2015

Overview

Inflammation and oxidative stress are central in many disease states. The major anti-oxidative enzymes contain selenium. The selenium intake in Europe is low, and supplementation with selenium and coenzyme Q10, important anti-oxidants, was evaluated in a previous study. The aim of this study was to evaluate response on the inflammatory biomarkers C-reactive protein, and sP-selectin, and their possible impact on cardiovascular mortality. 437 elderly individuals were included in the study. Clinical examination, echocardiography, electrocardiography and blood samples were drawn. The intervention time was 48 months, and median follow-up was 5.2 years. The effects on inflammation/atherosclerosis were evaluated through analyses of CRP and sP-selectin. Evaluations of the effect of the intervention was performed using repeated measures of variance. All mortality was registered, and endpoints of mortality were assessed by Kaplan-Meier plots. The placebo group showed a CRP level of 4.8 ng/mL at the start, and 5.1 ng/mL at the study end. The active supplementation group showed a CRP level of 4.1 ng/mL at the start, and 2.1 ng/mL at the study end. SP-selectin exhibited a level of 56.6 mg/mL at the start in the placebo group and 72.3 mg/mL at the study end, and in the active group the corresponding figures were 55.9 mg/mL and 58.0 mg/mL. A significantly smaller increase was demonstrated through repeated measurements of the two biomarkers in those on active supplementation. Active supplementation showed an effect on the CRP and sP-selectin levels, irrespective of the biomarker levels. Reduced cardiovascular mortality was demonstrated in both those with high and low levels of CRP and sP-selectin in the active supplementation group. CRP and sP-selectin showed significant changes reflecting effects on inflammation and atherosclerosis in those given selenium and coenzyme Q10 combined. A reduced cardiovascular mortality could be demonstrated in the active group, irrespective of biomarker level. This result should be regarded as hypothesis-generating, and it is hoped it will stimulate more research in the area.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Age / Aged / Aged, 80 and over / Antioxidants / Antioxidants (Nutrients) / Arteriosclerosis / Atherosclerosis / Bioindicators / Biomarkers / Biomarkers - metabolism / C-reactive protein / C-Reactive Protein - metabolism / Cardiology / Cardiovascular disease / Cardiovascular diseases / Cardiovascular Diseases - diet therapy / Cardiovascular Diseases - metabolism / Cardiovascular Diseases - mortality / Care and treatment / Clinical trials / Coenzyme Q10 / Complications and side effects / Coronary vessels / Diet / Dietary Supplements / Double-Blind Method / Early Intervention (Education) / Echocardiography / EKG / Electrocardiography / Enzyme-Linked Immunosorbent Assay / Enzymes / Female / Gene expression / Geriatrics / Health sciences / Heart failure / Humans / Immunoenzyme Techniques / Inflammation / Inflammation - diet therapy / Inflammation - metabolism / Inflammation - mortality / Intervention / Male / Mortality / Older people / Oxidants / Oxidative Stress / Oxidizing agents / P-Selectin - metabolism / Physiological aspects / Population / Prognosis / Prospective Studies / Secondary analysis / Selenium / Selenium (Chemical element) / Selenium - administration & dosage / Survival Rate / Ubiquinone - administration & dosage / Ubiquinone - analogs & derivatives