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Interactions between the microbiota and pathogenic bacteria in the gut
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Journal Article
Interactions between the microbiota and pathogenic bacteria in the gut
2016
Overview
The microbiome has an important role in human health. Changes in the microbiota can confer resistance to or promote infection by pathogenic bacteria. Antibiotics have a profound impact on the microbiota that alters the nutritional landscape of the gut and can lead to the expansion of pathogenic populations. Pathogenic bacteria exploit microbiota-derived sources of carbon and nitrogen as nutrients and regulatory signals to promote their own growth and virulence. By eliciting inflammation, these bacteria alter the intestinal environment and use unique systems for respiration and metal acquisition to drive their expansion. Unravelling the interactions between the microbiota, the host and pathogenic bacteria will produce strategies for manipulating the microbiota against infectious diseases.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Animals
/ Anti-Bacterial Agents - pharmacology
/ Bacteria
/ Bacteria - growth & development
/ Bacterial Infections - metabolism
/ Bacterial Infections - microbiology
/ Bacterial Infections - therapy
/ Gastrointestinal Microbiome - drug effects
/ Humanities and Social Sciences
/ Humans
/ Intestinal Mucosa - metabolism
/ Microbial Interactions - drug effects
/ Science
/ Studies
