Asset Details
Do you wish to reserve the book?
Comparative metabolomics reveals the metabolic variations between two endangered Taxus species (T. fuana and T. yunnanensis) in the Himalayas
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Comparative metabolomics reveals the metabolic variations between two endangered Taxus species (T. fuana and T. yunnanensis) in the Himalayas
Do you wish to request the book?
Comparative metabolomics reveals the metabolic variations between two endangered Taxus species (T. fuana and T. yunnanensis) in the Himalayas
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Comparative metabolomics reveals the metabolic variations between two endangered Taxus species (T. fuana and T. yunnanensis) in the Himalayas
2018
Overview
Background
Plants of the genus
Taxus
have attracted much attention owing to the natural product taxol, a successful anti-cancer drug.
T. fuana
and
T. yunnanensis
are two endangered
Taxus
species mainly distributed in the Himalayas. In our study, an untargeted metabolomics approach integrated with a targeted UPLC-MS/MS method was applied to examine the metabolic variations between these two
Taxus
species growing in different environments.
Results
The level of taxol in
T. yunnanensis
is much higher than that in
T. fuana
, indicating a higher economic value of
T. yunnanensis
for taxol production. A series of specific metabolites, including precursors, intermediates, competitors of taxol, were identified. All the identified intermediates are predominantly accumulated in
T. yunnanensis
than
T. fuana
, giving a reasonable explanation for the higher accumulation of taxol in
T. yunnanensis
. Taxusin and its analogues are highly accumulated in
T. fuana
, which may consume limited intermediates and block the metabolic flow towards taxol. The contents of total flavonoids and a majority of tested individual flavonoids are significantly accumulated in
T. fuana
than
T. yunnanensis
, indicating a stronger environmental adaptiveness of
T. fuana
.
Conclusions
Systemic metabolic profiling may provide valuable information for the comprehensive industrial utilization of the germplasm resources of these two endangered
Taxus
species growing in different environments.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
