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Wide-range screening of anti-inflammatory compounds in tomato using LC-MS and elucidating the mechanism of their functions
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Wide-range screening of anti-inflammatory compounds in tomato using LC-MS and elucidating the mechanism of their functions
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Journal Article
Wide-range screening of anti-inflammatory compounds in tomato using LC-MS and elucidating the mechanism of their functions
2018
Overview
Obesity-induced chronic inflammation is a key factor in type 2 diabetes. A vicious cycle involving pro-inflammatory mediators between adipocytes and macrophages is a common cause of chronic inflammation in the adipose tissue. Tomato is one of the most popular vegetables and is associated with a reduced risk of diabetes. However, the molecular mechanism underlying the effect of tomato on diabetes is unclear. In this study, we focused on anti-inflammatory compounds in tomato. We found that the extract of tomato reduced plasma glucose and inflammatory markers in mice. We screened anti-inflammatory fractions in tomato using lipopolysaccharide-stimulated RAW264.7 macrophages, and active compounds were estimated by liquid chromatography-mass spectrometry over a wide range. Surprisingly, a large number of compounds including oxylipin and coumarin derivatives were estimated as anti-inflammatory compounds. Especially, 9-oxo-octadecadienoic acid and daphnetin suppressed pro-inflammatory cytokines in RAW264.7 macrophages inhibiting mitogen-activated protein kinase phosphorylation and inhibitor of kappa B α protein degradation. These findings suggest that tomato containing diverse anti-inflammatory compounds ameliorates chronic inflammation in obese adipose tissue.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Adipose Tissue - drug effects
/ Animals
/ Anti-Inflammatory Agents - chemistry
/ Anti-Inflammatory Agents - isolation & purification
/ Anti-Inflammatory Agents - pharmacology
/ Chromatography, High Pressure Liquid
/ Coumarins - isolation & purification
/ Diabetes
/ Diet
/ Drug Evaluation, Preclinical
/ Food
/ Glucose
/ Kinases
/ Lipids
/ Male
/ MAP Kinase Signaling System - drug effects
/ Medicine and Health Sciences
/ Mice
/ Obesity
/ Oxylipins - isolation & purification
/ Plant Extracts - isolation & purification
/ Plant Extracts - pharmacology
/ Proteins
/ Research and Analysis Methods
/ Rodents
/ Solanum lycopersicum - chemistry
/ Spectrometry, Mass, Electrospray Ionization
/ Tomatoes
