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Proof and evolutionary analysis of ancient genome duplication in the yeast Saccharomyces cerevisiae
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Proof and evolutionary analysis of ancient genome duplication in the yeast Saccharomyces cerevisiae
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Proof and evolutionary analysis of ancient genome duplication in the yeast Saccharomyces cerevisiae
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Journal Article
Proof and evolutionary analysis of ancient genome duplication in the yeast Saccharomyces cerevisiae
2004
Overview
Whole-genome duplication followed by massive gene loss and specialization has long been postulated as a powerful mechanism of evolutionary innovation. Recently, it has become possible to test this notion by searching complete genome sequence for signs of ancient duplication. Here, we show that the yeast
Saccharomyces cerevisiae
arose from ancient whole-genome duplication, by sequencing and analysing
Kluyveromyces waltii
, a related yeast species that diverged before the duplication. The two genomes are related by a 1:2 mapping, with each region of
K. waltii
corresponding to two regions of
S. cerevisiae
, as expected for whole-genome duplication. This resolves the long-standing controversy on the ancestry of the yeast genome, and makes it possible to study the fate of duplicated genes directly. Strikingly, 95% of cases of accelerated evolution involve only one member of a gene pair, providing strong support for a specific model of evolution, and allowing us to distinguish ancestral and derived functions.
Publisher
Nature Publishing Group UK,Nature Publishing,Nature Publishing Group
Subject
Biological and medical sciences
/ Fundamental and applied biological sciences. Psychology
/ Genomics
/ Growth, nutrition, metabolism, transports, enzymes. Molecular biology
/ Humanities and Social Sciences
/ Mycology
/ Saccharomyces cerevisiae - genetics
/ Saccharomyces cerevisiae Proteins - genetics
/ Science
/ Yeasts
