Journal Article

Survival in endometrial cancer in relation to minimally invasive surgery or open surgery – a Swedish Gynecologic Cancer Group (SweGCG) study

Hjerpe, Elisabet, Holmberg, Erik, Lundqvist, Elisabeth Åvall, Marcickiewicz, Janusz, Kjölhede, Preben, Tholander, Bengt, Högberg, Thomas, Rosenberg, Per, Stålberg, Karin, Bjurberg, Maria, Dahm-Kähler, Pernilla, Flöter-Rådestad, Angelique, Hellman, Kristina, Borgfeldt, Christer

2021

Overview

Background The aim of this study was to analyze overall survival in endometrial cancer patients’ FIGO stages I-III in relation to surgical approach; minimally invasive (MIS) or open surgery (laparotomy). Methods A population-based retrospective study of 7275 endometrial cancer patients included in the Swedish Quality Registry for Gynecologic Cancer diagnosed from 2010 to 2018. Cox proportional hazard models were used in univariable and multivariable survival analyses. Results In univariable analysis open surgery was associated with worse overall survival compared with MIS hazard ratio, HR, 1.39 (95% CI 1.18–1.63) while in the multivariable analysis, surgical approach (MIS vs open surgery) was not associated with overall survival after adjustment for known risk factors (HR 1.12, 95% CI 0.95–1.32). Higher FIGO stage, non-endometrioid histology, non-diploid tumors, lymphovascular space invasion and increasing age were independent risk factors for overall survival. Conclusion The minimal invasive or open surgical approach did not show any impact on survival for patients with endometrial cancer stages I-III when known prognostic risk factors were included in the multivariable analyses.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Age groups / Biomedical and Life Sciences / Biomedicine / Cancer / Cancer and Oncology / cancer imaging / Cancer och onkologi / Cancer Research / Care and treatment / Cervical cancer / Chemotherapy / Clinical Medicine / Diploids / Emigration / Endometrial cancer / Endometrium / Gynaecology, Obstetrics and Reproductive Medicine / Gynecology, Operative / Gynekologi, obstetrik och reproduktionsmedicin / Health Promotion and Disease Prevention / Histology / Hysterectomy / interventional therapeutics / Klinisk medicin / Laparoscopy / Laparotomy / Medical and Health Sciences / Medical prognosis / Medicin och hälsovetenskap / Medicine/Public Health / Minimally invasive surgery / Morphology / Oncology / Oophorectomy / Patient outcomes / Patients / Population / Population studies / Radiation therapy / Registration / Research Article / Risk factors / Surgery / Surgical Oncology / Survival / Tumors