Journal Article

Perioperative Non-Invasive Indocyanine Green-Clearance Testing to Predict Postoperative Outcome after Liver Resection

Pereyra, David, Reiter, Silvia, Stremitzer, Stefan, Brostjan, Christine, Starlinger, Patrick, Offensperger, Florian, Gruenberger, Thomas, Wanek, David, Haegele, Stefanie, Fleischmann, Edith

2016

Overview

Postoperative liver dysfunction may lead to morbidity and mortality after liver resection. Preoperative liver function assessment is critical to identify preexisting liver dysfunction in patients prior to resection. The aim of this study was to evaluate the predictive potential of perioperative indocyanine green (ICG)-clearance testing to prevent postoperative liver dysfunction and morbidity using standardized outcome parameters in a routine Western-clinical-setting. 137 patients undergoing partial hepatectomy between 2011 and 2013, at the general hospital of Vienna, were included. ICG-clearance was recorded one day prior to surgery as well as on the first and fifth postoperative day. Postoperative liver dysfunction was defined according to the International Study Group of Liver Surgery and evaluation of morbidity was based on the Dindo-Clavien classification. Statistical analyses were based on non-parametric tests. Preoperative reduced ICG-plasma disappearance rate (PDR) as well as increased ICG-retention rate at 15 min (R15) were able to significantly predict postoperative liver dysfunction (Area under the curve = PDR: 0.716, P = 0.018; R15: 0.719, P = 0.016). Furthermore, PDR <17%/min. or R15 >8%, were able to accurately predict postoperative complications prior to surgery. In addition to this, ICG-clearance on postoperative day 1 comparably predicted postoperative liver dysfunction (Area under the curve = PDR: 0.895; R15: 0.893; both P <0.001), specifically, PDR <10%/min or R15 >20% on postoperative day 1 predicted poor postoperative outcome. PDR and R15 may represent useful parameters to distinguish preoperative high and low risk patients in a Western collective as well as on postoperative day 1, to identify patients who require closer monitoring for potential complications.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Adult / Aged / Aged, 80 and over / Analysis / Biology and Life Sciences / Chemotherapy / Classification / Colorectal cancer / Complications / Design standards / Female / Health aspects / Hepatectomy / Hepatectomy - adverse effects / Hepatology / Hospitals / Humans / Indocyanine Green - metabolism / International studies / Laboratories / Liver / Liver - metabolism / Liver - surgery / Liver cancer / Liver diseases / Liver Function Tests / Male / Medical research / Medicine and Health Sciences / Middle Aged / Morbidity / Mortality / Oncology / Patients / Perioperative Period / Plasma / Postoperative period / Prognosis / Statistical analysis / Studies / Surgery / Surgical outcomes / Treatment Outcome / Young Adult