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The amphioxus genome and the evolution of the chordate karyotype
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The amphioxus genome and the evolution of the chordate karyotype
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Journal Article
The amphioxus genome and the evolution of the chordate karyotype
2008
Overview
Lancelets (‘amphioxus’) are the modern survivors of an ancient chordate lineage, with a fossil record dating back to the Cambrian period. Here we describe the structure and gene content of the highly polymorphic ∼520-megabase genome of the Florida lancelet
Branchiostoma floridae
, and analyse it in the context of chordate evolution. Whole-genome comparisons illuminate the murky relationships among the three chordate groups (tunicates, lancelets and vertebrates), and allow not only reconstruction of the gene complement of the last common chordate ancestor but also partial reconstruction of its genomic organization, as well as a description of two genome-wide duplications and subsequent reorganizations in the vertebrate lineage. These genome-scale events shaped the vertebrate genome and provided additional genetic variation for exploitation during vertebrate evolution.
The amphioxus genome: The key to the genetics of the last common chordate ancestor
This issue sees the publication of the draft genome sequence of an animal that has been studied by biologists for many years as a model for a primitive chordate. The amphioxus or lancelet is a small worm-like creature, usually to be found buried in sand on the sea floor. Comparative analysis of the genome of the Florida lancelet,
Branchiostoma floridae
, reveals 17 ancestral chordate linkage groups conserved in the modern amphioxus and vertebrate genomes despite more than half a billion years of independent evolution. From this it possible to make a virtual reconstruction of the 17 chromosomes of the last common chordate ancestor. This reconstruction conforms that two rounds of whole genome duplication have occurred during evolution of the jawed vertebrate lineage. And it illuminates the murky relationships between the three chordate groups, the tunicates, lancelets and vertebrates. The cover shows four adult amphioxus collected in Apalachee Bay, Florida, with anterior towards the top and dorsal to the right. Yellow ovals are gonads. (Photo by Nicholas Putnam, DOE Joint Genome Institute.
Publisher
Nature Publishing Group UK,Nature Publishing,Nature Publishing Group
Subject
/ Biological and medical sciences
/ Cambrian
/ Chordata
/ Classical genetics, quantitative genetics, hybrids
/ DNA Transposable Elements - genetics
/ Fundamental and applied biological sciences. Psychology
/ Genes
/ Genetics
/ Genetics of eukaryotes. Biological and molecular evolution
/ Genomes
/ Genomics
/ Humanities and Social Sciences
/ Humans
/ Identification and classification
/ Marine
/ Polymorphism, Genetic - genetics
/ Science
/ Studies
/ Synteny
