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Role of Lymphotoxin and the Type I TNF Receptor in the Formation of Germinal Centers
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Role of Lymphotoxin and the Type I TNF Receptor in the Formation of Germinal Centers
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Journal Article
Role of Lymphotoxin and the Type I TNF Receptor in the Formation of Germinal Centers
1996
Overview
In mice deficient in either lymphotoxin-α (LT-α) or the type I tumor necrosis factor (TNF) receptor, but not the type II TNF receptor, germinal centers failed to develop in peripheral lymphoid organs. Germinal center formation was restored in LT-α-deficient mice by transplantation of normal bone marrow, indicating that the LT-α-expressing cells required to establish this lymphoid structure are derived from bone marrow.
Publisher
American Society for the Advancement of Science,American Association for the Advancement of Science
Subject
Analysis of the immune response. Humoral and cellular immunity
/ Animals
/ Biological and medical sciences
/ Bones
/ Fundamental and applied biological sciences. Psychology
/ Germinal Center - immunology
/ Germinal Center - physiology
/ Lymphokines, interleukins ( function, expression)
/ Lymphotoxin-alpha - genetics
/ Lymphotoxin-alpha - physiology
/ Mice
/ Receptors, Tumor Necrosis Factor - genetics
/ Receptors, Tumor Necrosis Factor - physiology
/ Regulatory factors and their cellular receptors
/ Spleen
