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Resveratrol Partially Attenuates Lung Responses to Diesel Exhaust in Aged Mice
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Resveratrol Partially Attenuates Lung Responses to Diesel Exhaust in Aged Mice
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Resveratrol Partially Attenuates Lung Responses to Diesel Exhaust in Aged Mice
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Journal Article
Resveratrol Partially Attenuates Lung Responses to Diesel Exhaust in Aged Mice
2026
Overview
Despite scientific evidence and government actions aimed at reducing air pollution, it remains a major public health issue in large urban centers, compromising human health, particularly among the most vulnerable populations, including the elderly. Polyphenolic compounds are believed to have antiaging effects, reducing DNA damage and exhibiting anti‐inflammatory and antioxidant properties. The polyphenol resveratrol (Resv) has demonstrated protective effects in the lungs against harmful stimuli in adult mice; however, few studies have extended these investigations to elderly animals, which have reduced antioxidant responses. This study aimed to evaluate the effects of Resv on the lungs of 15‐month‐old mice exposed to diesel exhaust (DE). Animals were exposed to 1200 µg/m3 of PM2.5 over 30 consecutive days. Resv (1200 µg/m3) was administered for 40 days, beginning 10 days before DE exposure. We evaluated the inflammatory profile in bronchoalveolar lavage fluid (BALF) and serum; quantified macrophages; and assessed antioxidant enzymes (glutathione peroxidase [GPx], glutathione reductase [GR], glutathione‐S‐transferase [GST], and copper/zinc superoxide dismutase [Cu/Zn SOD]), 8‐OHdG, 8‐iso‐prostaglandin F2α (8‐isoprostane), collagen and elastic fiber content, and sirtuin protein levels (Sirt1, Sirt2, and Sirt6) in the lung parenchyma. Resv administration increased GR and Sirt1 levels and decreased Sirt2 levels. DE caused inflammatory changes in BALF and lung tissue, increased 8‐OHdG and 8‐isoprostane levels, and modulated antioxidant enzymes, sirtuins, and lung collagen. Resv administration after DE exposure did not significantly alter 8‐OHdG, antioxidant enzymes, sirtuins, or collagen levels in the lungs, but it reduced BALF cellularity and IL‐1β and 8‐isoprostane levels. Our data suggest moderate protective effects of Resv in aged lungs exposed to DE.
