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Donor kidney pathology combined with clinical parameters helps expand the kidney donor pool: a large-scale retrospective cohort study
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Donor kidney pathology combined with clinical parameters helps expand the kidney donor pool: a large-scale retrospective cohort study
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Journal Article
Donor kidney pathology combined with clinical parameters helps expand the kidney donor pool: a large-scale retrospective cohort study
2025
Overview
The disparity between kidney demand and supply necessitates the expansion of the donor pool. This study evaluates the long-term outcomes of single kidney transplantation guided by histological and clinical parameters.
We retrospectively analyzed 1,024 adult recipients of deceased-donor kidney transplants from January 2011 to December 2020. Graft and patient survival were assessed using Kaplan-Meier analysis, and independent risk factors were identified through Cox regression models. Donor kidney histological specimens were evaluated using the Remuzzi score.
A Remuzzi score of 4 emerged as a critical threshold for safe single kidney transplantation. Recipients were divided into three groups based on Remuzzi score (0-3, 4, and >4). Those with a score of 4 had similar 10-year graft survival to those with score 0-3 (92.0% vs. 92.0%,
= 0.984), whereas grafts with score >4 had poorer outcomes (82.0%,
= 0.033). The 10-year patient survival for recipients with a score of 4 was comparable to those with scores 0-3 (90.0% vs. 94.0%,
= 0.122), while score >4 trended toward worse survival (81.0%,
= 0.067). In subgroup analyses of high Remuzzi scores (>4,
= 105), the Kidney Donor Profile Index (KDPI) and donor terminal creatinine were identified as independent risk factors for graft loss.
Single kidney transplantation is safe for grafts with Remuzzi scores ≤4. Even some kidneys from high-score donors demonstrated favorable graft prognosis when allocated based on KDPI and donor terminal creatinine.
Publisher
Taylor & Francis Group
Subject
/ Expanded criteria donors/ECD
/ Female
/ Humans
/ Kidney Failure, Chronic - surgery
/ Kidney Transplantation - adverse effects
/ Kidney Transplantation - methods
/ Kidney Transplantation - mortality
/ Kidney Transplantation - statistics & numerical data
/ Male
/ single kidney transplantation
