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Cytotoxic and Antimicrobial Activity of the Ageratina Genus
by
Arias-Ataide, Dulce María
, Valladares-Cisneros, María Guadalupe
, Salinas-Marín, Roberta
, Avilés-Montes, Dante
, Rodríguez-López, Verónica
, Sotelo-Leyva, César
, Abarca-Vargas, Rodolfo
, Salinas-Sánchez, David Osvaldo
, Bustos Rivera-Bahena, Genoveva
, Rojas-Jiménez, Sarai
, Figueroa-Brito, Rodolfo
in
Ageratina
/ Ageratina - chemistry
/ Anti-Infective Agents - chemistry
/ Anti-Infective Agents - pharmacology
/ Antimicrobial agents
/ Antineoplastic Agents, Phytogenic - chemistry
/ Antineoplastic Agents, Phytogenic - pharmacology
/ cancer cell lines
/ Cancer therapies
/ Cell cycle
/ Cell Line, Tumor
/ Cytotoxicity
/ Fungal infections
/ Fungi
/ Gram-positive and Gram-negative microorganisms
/ Herbal medicine
/ Humans
/ Microbial Sensitivity Tests
/ Microorganisms
/ Natural products
/ Plant Extracts - chemistry
/ Plant Extracts - pharmacology
/ Plants, Medicinal - chemistry
/ Review
/ Staphylococcus infections
/ Systematic review
/ Traditional medicine
/ Viral infections
/ yeast
2025
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Cytotoxic and Antimicrobial Activity of the Ageratina Genus
by
Arias-Ataide, Dulce María
, Valladares-Cisneros, María Guadalupe
, Salinas-Marín, Roberta
, Avilés-Montes, Dante
, Rodríguez-López, Verónica
, Sotelo-Leyva, César
, Abarca-Vargas, Rodolfo
, Salinas-Sánchez, David Osvaldo
, Bustos Rivera-Bahena, Genoveva
, Rojas-Jiménez, Sarai
, Figueroa-Brito, Rodolfo
in
Ageratina
/ Ageratina - chemistry
/ Anti-Infective Agents - chemistry
/ Anti-Infective Agents - pharmacology
/ Antimicrobial agents
/ Antineoplastic Agents, Phytogenic - chemistry
/ Antineoplastic Agents, Phytogenic - pharmacology
/ cancer cell lines
/ Cancer therapies
/ Cell cycle
/ Cell Line, Tumor
/ Cytotoxicity
/ Fungal infections
/ Fungi
/ Gram-positive and Gram-negative microorganisms
/ Herbal medicine
/ Humans
/ Microbial Sensitivity Tests
/ Microorganisms
/ Natural products
/ Plant Extracts - chemistry
/ Plant Extracts - pharmacology
/ Plants, Medicinal - chemistry
/ Review
/ Staphylococcus infections
/ Systematic review
/ Traditional medicine
/ Viral infections
/ yeast
2025
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Cytotoxic and Antimicrobial Activity of the Ageratina Genus
by
Arias-Ataide, Dulce María
, Valladares-Cisneros, María Guadalupe
, Salinas-Marín, Roberta
, Avilés-Montes, Dante
, Rodríguez-López, Verónica
, Sotelo-Leyva, César
, Abarca-Vargas, Rodolfo
, Salinas-Sánchez, David Osvaldo
, Bustos Rivera-Bahena, Genoveva
, Rojas-Jiménez, Sarai
, Figueroa-Brito, Rodolfo
in
Ageratina
/ Ageratina - chemistry
/ Anti-Infective Agents - chemistry
/ Anti-Infective Agents - pharmacology
/ Antimicrobial agents
/ Antineoplastic Agents, Phytogenic - chemistry
/ Antineoplastic Agents, Phytogenic - pharmacology
/ cancer cell lines
/ Cancer therapies
/ Cell cycle
/ Cell Line, Tumor
/ Cytotoxicity
/ Fungal infections
/ Fungi
/ Gram-positive and Gram-negative microorganisms
/ Herbal medicine
/ Humans
/ Microbial Sensitivity Tests
/ Microorganisms
/ Natural products
/ Plant Extracts - chemistry
/ Plant Extracts - pharmacology
/ Plants, Medicinal - chemistry
/ Review
/ Staphylococcus infections
/ Systematic review
/ Traditional medicine
/ Viral infections
/ yeast
2025
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Cytotoxic and Antimicrobial Activity of the Ageratina Genus
Journal Article
Cytotoxic and Antimicrobial Activity of the Ageratina Genus
2025
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Overview
Medicinal plants have long been used for therapeutic purposes in many cultures. They represent sources of important bioactive compounds, often of pharmacological significance.
Spach is the largest genus in Mexico and is characterised by its traditional use in the treatment of cancer and infections of the skin, blood, and intestines. Different species of
have been biologically evaluated at the extract and compound levels, and their chemical contents have been purified and characterised. Following a PRISMA meta-analysis, 29 scientific reports were selected and analysed. Tables of different
species were integrated to compare their cytotoxic and antimicrobial activity at the extract and compound levels. Twelve pure and isolated natural compounds were tested for cytotoxic activity against several cell lines from lung, colon, and breast cancer, cervical carcinoma, hepatocarcinoma, promyelocytic leukaemia, and histiocytic lymphoma. Forty-one pure and isolated natural compounds were evaluated for antimicrobial activity against a wide spectrum of microorganisms, including Gram-positive and Gram-negative bacteria, yeast, fungi, parasites and viruses.
Spach contains cytotoxic and antimicrobial substances with broad chemical profiles. In addition to being a plant with active compounds, it could be useful for future rational drug design.
Publisher
MDPI AG,Multidisciplinary Digital Publishing Institute (MDPI)
Subject
/ Anti-Infective Agents - chemistry
/ Anti-Infective Agents - pharmacology
/ Antineoplastic Agents, Phytogenic - chemistry
/ Antineoplastic Agents, Phytogenic - pharmacology
/ Fungi
/ Gram-positive and Gram-negative microorganisms
/ Humans
/ Plant Extracts - pharmacology
/ Plants, Medicinal - chemistry
/ Review
/ yeast
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