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噻唑烷二酮的使用与2型糖尿病患者痴呆风险降低相关:一项回顾性队列研究
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Journal Article
噻唑烷二酮的使用与2型糖尿病患者痴呆风险降低相关:一项回顾性队列研究
2023
Overview
摘要 背景:2型糖尿病(T2DM)和痴呆给患者带来严重的健康负担，但目前很少有研究探讨降糖药物与痴呆风险之间的关系。我们旨在评估T2DM人群中噻唑烷二酮类药物的使用与痴呆发病率之间的关系。 研究设计和方法:利用鄞州地区卫生保健数据库，对新使用噻唑烷二酮(TZDs)或α‐糖苷酶抑制剂(AGIs)的2型糖尿病患者进行回顾性队列研究。采用治疗加权逆概率(IPTW)控制潜在发病的Cox模型来估计TZD使用与痴呆风险之间的关联的风险比(HR)。 结果:最终队列共纳入49823名AGIs新用户和12752名TZDs新用户。在初步分析中，AGIs和TZDs使用者的痴呆发病率分别为每10万人195.7/年和78.2/年。在使用IPTW进行潜在混杂调整后，TZDs的使用与痴呆事件风险降低相关，HR为0.51(95%CI,0.38‐0.67)。不同亚组分析和敏感性分析的结果与初步分析的结果一致。 结论:在2型糖尿病人群中，使用TZDs与痴呆发病率降低相关。
Publisher
John Wiley & Sons, Inc,Wiley
Subject
