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Persistence of vaccine-elicited immune response up to 14 years post-HIV gp120-NefTat/AS01 B vaccination

by Yates, Nicole L , Jongert, Erik , Leroux-Roels, Isabel , Aerssens, Annelies , Mesia Vela, Doris , Roman, François , Sawant, Sheetal , Janssens, Michel , Van Der Meeren, Olivier , Seaton, Kelly E , Koutsoukos, Marguerite , Leroux-Roels, Geert , Tomaras, Georgia D , Brackett, Caroline , Debois, Muriel

in Adult / AIDS Vaccines - immunology / Allergy and Immunology / Antibodies / Antibody Formation / Antigens / Binding / CD4 antigen / CD40L protein / CD8 antigen / Cell-mediated immunity / Cytokines / Glycoprotein gp120 / Glycoproteins / Health risks / HIV / HIV Antibodies - blood / HIV Envelope Protein gp120 - immunology / HIV Infections - prevention & control / HIV-1 / Human immunodeficiency virus / Humans / Immune response / Immune system / Immunity, Cellular / Immunoglobulin G / Infections / Interferon / Interleukin 2 / Lymphocytes T / Objectives / Proteins / Response rates / Scaffolds / Tumor necrosis factor-α / Vaccination / Vaccines / Viruses / γ-Interferon

2020

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Persistence of vaccine-elicited immune response up to 14 years post-HIV gp120-NefTat/AS01 B vaccination

2020

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Persistence of vaccine-elicited immune response up to 14 years post-HIV gp120-NefTat/AS01 B vaccination

2020

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Journal Article

Persistence of vaccine-elicited immune response up to 14 years post-HIV gp120-NefTat/AS01 B vaccination

Yates, Nicole L,

Jongert, Erik,

Leroux-Roels, Isabel,

Aerssens, Annelies,

Mesia Vela, Doris,

Roman, François,

Sawant, Sheetal,

Janssens, Michel,

Van Der Meeren, Olivier,

Seaton, Kelly E,

Koutsoukos, Marguerite,

Leroux-Roels, Geert,

Tomaras, Georgia D,

Brackett, Caroline,

Debois, Muriel

2020

Overview

Highlights•Long-term immune response induced by the candidate gp120-NefTat/AS01B vaccine was evaluated. •Antibodies binding to a HIV gp120 antigen panel persisted over 14 years post-vaccination. •Persistence of antibodies binding to the V1V2 scaffold was noted 2–14 years post-vaccination. •Polyfunctional gp120-specific CD4+T-cells were detected up to 14 years post-vaccination.

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Publisher

Elsevier Limited

Subject

Adult

/ AIDS Vaccines - immunology

/ Allergy and Immunology

/ Antibodies

/ Antibody Formation

/ Antigens

/ Binding