Asset Details
Do you wish to reserve the book?
Higher serum bicarbonate levels within the normal range are associated with better survival and renal outcomes in African Americans
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Higher serum bicarbonate levels within the normal range are associated with better survival and renal outcomes in African Americans
Do you wish to request the book?
Higher serum bicarbonate levels within the normal range are associated with better survival and renal outcomes in African Americans
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Higher serum bicarbonate levels within the normal range are associated with better survival and renal outcomes in African Americans
2011
Overview
Recent studies suggest that correcting low serum bicarbonate levels may reduce the progression of kidney disease; however, few patients with chronic kidney disease have low serum bicarbonate. Therefore, we examined whether higher levels of serum bicarbonate within the normal range (20–30mmol/l) were associated with better kidney outcomes in the African American Study of Kidney Disease and Hypertension (AASK) trial. At baseline and during follow-up of 1094 patients, the glomerular filtration rates (GFR) were measured by iothalamate clearances and events were adjudicated by the outcomes committee. Mean baseline serum bicarbonate, measured GFR, and proteinuria were 25.1mmol/l, 46ml/min per 1.73m2, and 326mg/g of creatinine, respectively. Each 1mmol/l increase in serum bicarbonate within the normal range was associated with reduced risk of death, dialysis, or GFR event and with dialysis or GFR event (hazard ratios of 0.942 and 0.932, respectively) in separate multivariable Cox regression models that included errors-in-variables calibration. Cubic spline regression showed that the lowest risk of GFR event or dialysis was found at serum bicarbonate levels near 28–30mmol/l. Thus, our study suggests that serum bicarbonate is an independent predictor of CKD progression. Whether increasing serum bicarbonate into the high-normal range will improve kidney outcomes during interventional studies will need to be considered.
Publisher
Elsevier Inc,Nature Publishing Group,Elsevier Limited
Subject
AASK (African American Study of Kidney Disease and Hypertension)
/ acidosis
/ Adult
/ African Americans - statistics & numerical data
/ Aged
/ Antihypertensive Agents - therapeutic use
/ Arterial hypertension. Arterial hypotension
/ Biological and medical sciences
/ Female
/ Humans
/ Hypertension - physiopathology
/ Kidney Diseases - physiopathology
/ Kidney Diseases - prevention & control
/ Kidneys
/ Male
/ Nephrology. Urinary tract diseases
/ Serum
/ survival
/ Urinary system involvement in other diseases. Miscellaneous
