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A Placebo-Controlled Trial of Subcutaneous Semaglutide in Nonalcoholic Steatohepatitis
by
Okanoue, Takeshi
, Newsome, Philip
, Sanyal, Arun
, Harrison, Stephen
, Buchholtz, Kristine
, Bureau, Christophe
, Ratziu, Vlad
, Institut de Recherche en Santé Digestive (IRSD) ; Université Toulouse III - Paul Sabatier (UT3) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT) ; Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
, Sejling, Anne-Sophie
, Cusi, Kenneth
, Linder, Martin
in
Adolescent
/ Adult
/ Aged
/ Amylases - blood
/ Antidiabetics
/ Biopsy
/ Constipation
/ Diabetes
/ Diabetes Mellitus, Type 2 - complications
/ Diabetes Mellitus, Type 2 - drug therapy
/ Dosage
/ Dose-Response Relationship, Drug
/ Double-Blind Method
/ Enzymes
/ Female
/ Fibrosis
/ GLP-1 receptor agonists
/ Glucagon
/ Glucagon-like peptide 1
/ Glucagon-Like Peptides - administration & dosage
/ Glucagon-Like Peptides - adverse effects
/ Humans
/ Inflammation
/ Injections, Subcutaneous
/ Insulin resistance
/ Life Sciences
/ Lipase - blood
/ Liver - pathology
/ Liver Cirrhosis - drug therapy
/ Liver Cirrhosis - etiology
/ Liver Cirrhosis - pathology
/ Liver diseases
/ Male
/ Metabolism
/ Middle Aged
/ Morbidity
/ Nausea
/ Non-alcoholic Fatty Liver Disease - blood
/ Non-alcoholic Fatty Liver Disease - complications
/ Non-alcoholic Fatty Liver Disease - drug therapy
/ Non-alcoholic Fatty Liver Disease - pathology
/ Patients
/ Placebos
/ Statistical analysis
/ Vomiting
/ Weight control
/ Young Adult
2021
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A Placebo-Controlled Trial of Subcutaneous Semaglutide in Nonalcoholic Steatohepatitis
by
Okanoue, Takeshi
, Newsome, Philip
, Sanyal, Arun
, Harrison, Stephen
, Buchholtz, Kristine
, Bureau, Christophe
, Ratziu, Vlad
, Institut de Recherche en Santé Digestive (IRSD) ; Université Toulouse III - Paul Sabatier (UT3) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT) ; Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
, Sejling, Anne-Sophie
, Cusi, Kenneth
, Linder, Martin
in
Adolescent
/ Adult
/ Aged
/ Amylases - blood
/ Antidiabetics
/ Biopsy
/ Constipation
/ Diabetes
/ Diabetes Mellitus, Type 2 - complications
/ Diabetes Mellitus, Type 2 - drug therapy
/ Dosage
/ Dose-Response Relationship, Drug
/ Double-Blind Method
/ Enzymes
/ Female
/ Fibrosis
/ GLP-1 receptor agonists
/ Glucagon
/ Glucagon-like peptide 1
/ Glucagon-Like Peptides - administration & dosage
/ Glucagon-Like Peptides - adverse effects
/ Humans
/ Inflammation
/ Injections, Subcutaneous
/ Insulin resistance
/ Life Sciences
/ Lipase - blood
/ Liver - pathology
/ Liver Cirrhosis - drug therapy
/ Liver Cirrhosis - etiology
/ Liver Cirrhosis - pathology
/ Liver diseases
/ Male
/ Metabolism
/ Middle Aged
/ Morbidity
/ Nausea
/ Non-alcoholic Fatty Liver Disease - blood
/ Non-alcoholic Fatty Liver Disease - complications
/ Non-alcoholic Fatty Liver Disease - drug therapy
/ Non-alcoholic Fatty Liver Disease - pathology
/ Patients
/ Placebos
/ Statistical analysis
/ Vomiting
/ Weight control
/ Young Adult
2021
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A Placebo-Controlled Trial of Subcutaneous Semaglutide in Nonalcoholic Steatohepatitis
by
Okanoue, Takeshi
, Newsome, Philip
, Sanyal, Arun
, Harrison, Stephen
, Buchholtz, Kristine
, Bureau, Christophe
, Ratziu, Vlad
, Institut de Recherche en Santé Digestive (IRSD) ; Université Toulouse III - Paul Sabatier (UT3) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT) ; Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
, Sejling, Anne-Sophie
, Cusi, Kenneth
, Linder, Martin
in
Adolescent
/ Adult
/ Aged
/ Amylases - blood
/ Antidiabetics
/ Biopsy
/ Constipation
/ Diabetes
/ Diabetes Mellitus, Type 2 - complications
/ Diabetes Mellitus, Type 2 - drug therapy
/ Dosage
/ Dose-Response Relationship, Drug
/ Double-Blind Method
/ Enzymes
/ Female
/ Fibrosis
/ GLP-1 receptor agonists
/ Glucagon
/ Glucagon-like peptide 1
/ Glucagon-Like Peptides - administration & dosage
/ Glucagon-Like Peptides - adverse effects
/ Humans
/ Inflammation
/ Injections, Subcutaneous
/ Insulin resistance
/ Life Sciences
/ Lipase - blood
/ Liver - pathology
/ Liver Cirrhosis - drug therapy
/ Liver Cirrhosis - etiology
/ Liver Cirrhosis - pathology
/ Liver diseases
/ Male
/ Metabolism
/ Middle Aged
/ Morbidity
/ Nausea
/ Non-alcoholic Fatty Liver Disease - blood
/ Non-alcoholic Fatty Liver Disease - complications
/ Non-alcoholic Fatty Liver Disease - drug therapy
/ Non-alcoholic Fatty Liver Disease - pathology
/ Patients
/ Placebos
/ Statistical analysis
/ Vomiting
/ Weight control
/ Young Adult
2021
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A Placebo-Controlled Trial of Subcutaneous Semaglutide in Nonalcoholic Steatohepatitis
Journal Article
A Placebo-Controlled Trial of Subcutaneous Semaglutide in Nonalcoholic Steatohepatitis
2021
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Overview
Patients with nonalcoholic steatohepatitis were randomly assigned to receive subcutaneous semaglutide or placebo. The incidence of NASH resolution was significantly higher with semaglutide than with placebo, but the between-group difference in the incidence of an improvement in fibrosis stage was not significant.
Publisher
Massachusetts Medical Society,CCSD
Subject
/ Adult
/ Aged
/ Biopsy
/ Diabetes
/ Diabetes Mellitus, Type 2 - complications
/ Diabetes Mellitus, Type 2 - drug therapy
/ Dosage
/ Dose-Response Relationship, Drug
/ Enzymes
/ Female
/ Fibrosis
/ Glucagon
/ Glucagon-Like Peptides - administration & dosage
/ Glucagon-Like Peptides - adverse effects
/ Humans
/ Liver Cirrhosis - drug therapy
/ Male
/ Nausea
/ Non-alcoholic Fatty Liver Disease - blood
/ Non-alcoholic Fatty Liver Disease - complications
/ Non-alcoholic Fatty Liver Disease - drug therapy
/ Non-alcoholic Fatty Liver Disease - pathology
/ Patients
/ Placebos
/ Vomiting
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