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AtsPLA₂-α nuclear relocalization by the Arabidopsis transcription factor AtMYB30 leads to repression of the plant defense response
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AtsPLA₂-α nuclear relocalization by the Arabidopsis transcription factor AtMYB30 leads to repression of the plant defense response
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Journal Article
AtsPLA₂-α nuclear relocalization by the Arabidopsis transcription factor AtMYB30 leads to repression of the plant defense response
2010
Overview
The hypersensitive response (HR), characterized by a rapid and localized cell death at the inoculation site, is one of the most efficient resistance reactions to pathogen attack in plants. The transcription factor AtMYB30 was identified as a positive regulator of the HR and resistance responses during interactions between Arabidopsis and bacteria. Here, we show that AtMYB30 and the secreted phospholipase AtsPLA₂-α physically interact in vivo, following the AtMYB30-mediated specific relocalization of AtsPLA₂-α from cytoplasmic vesicles to the plant cell nucleus. This protein interaction leads to repression of AtMYB30 transcriptional activity and negative regulation of plant HR. Moreover, Atspla₂-α mutant plants are more resistant to bacterial inoculation, whereas AtsPLA₂-α overexpression leads to decreased resistance, confirming that AtsPLA₂-α is a negative regulator of AtMYB30-mediated defense. These data underline the importance of cellular dynamics and, particularly, protein translocation to the nucleus, for defense-associated gene regulation in plants.
Publisher
National Academy of Sciences,National Acad Sciences
Subject
Active Transport, Cell Nucleus
/ Arabidopsis Proteins - genetics
/ Arabidopsis Proteins - metabolism
/ bacteria
/ Gene Expression Regulation, Enzymologic
/ Gene Expression Regulation, Plant
/ genes
/ Genetic Complementation Test
/ mutants
/ Mutation
/ Phospholipases A2, Secretory - genetics
/ Phospholipases A2, Secretory - metabolism
/ Plant Diseases - microbiology
/ Plants, Genetically Modified
/ Pseudomonas syringae - pathogenicity
/ Transcription Factors - genetics
