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Position paper: Rationale for the treatment of Wilms tumour in the UMBRELLA SIOP-RTSG 2016 protocol

by Gessler, Manfred , Verschuur, Arnauld C , van den Heuvel-Eibrink, Marry M , Smets, Anne M , Collini, Paola , Hol, Janna A , Leuschner, Ivo , Segers, Heidi , Rübe, Christian , Janssens, Geert O , de Camargo, Beatriz , Spreafico, Filippo , Furtwängler, Rhoikos , Pritchard-Jones, Kathy , Godzinski, Jan , Ramírez-Villar, Gema L , Bergeron, Christophe , van Tinteren, Harm , Brok, Jesper , Graf, Norbert , Vujanic, Gordan M

in Antineoplastic Combined Chemotherapy Protocols / Care and treatment / Child / Child, Preschool / Collaboration / Dactinomycin / Diagnosis / Evaluation / Humans / Infant / Kidney Neoplasms - pathology / Kidney Neoplasms - therapy / Medical protocols / Nephroblastoma / Patient Selection / Practice Guidelines as Topic / Tumors / Vincristine / Wilms Tumor - pathology / Wilms Tumor - therapy

2017

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Position paper: Rationale for the treatment of Wilms tumour in the UMBRELLA SIOP-RTSG 2016 protocol

2017

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Position paper: Rationale for the treatment of Wilms tumour in the UMBRELLA SIOP-RTSG 2016 protocol

2017

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Journal Article

Position paper: Rationale for the treatment of Wilms tumour in the UMBRELLA SIOP-RTSG 2016 protocol

Gessler, Manfred,

Verschuur, Arnauld C,

van den Heuvel-Eibrink, Marry M,

Smets, Anne M,

Collini, Paola,

Hol, Janna A,

Leuschner, Ivo,

Segers, Heidi,

Rübe, Christian,

Janssens, Geert O,

de Camargo, Beatriz,

Spreafico, Filippo,

Furtwängler, Rhoikos,

Pritchard-Jones, Kathy,

Godzinski, Jan,

Ramírez-Villar, Gema L,

Bergeron, Christophe,

van Tinteren, Harm,

Brok, Jesper,

Graf, Norbert,

Vujanic, Gordan M

2017

Overview

The Renal Tumour Study Group of the International Society of Paediatric Oncology (SIOP-RTSG) has developed a new protocol for the diagnosis and treatment of childhood renal tumours, the UMBRELLA SIOP-RTSG 2016 (the UMBRELLA protocol), to continue international collaboration in the treatment of childhood renal tumours. This protocol will support integrated biomarker and imaging research, focussing on assessing the independent prognostic value of genomic changes within the tumour and the volume of the blastemal component that survives preoperative chemotherapy. Treatment guidelines for Wilms tumours in the UMBRELLA protocol include recommendations for localized, metastatic, and bilateral disease, for all age groups, and for relapsed disease. These recommendations have been established by a multidisciplinary panel of leading experts on renal tumours within the SIOP-RTSG. The UMBRELLA protocol should promote international collaboration and research and serve as the SIOP-RTSG best available treatment standard.

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Publisher

Nature Publishing Group

Subject

Antineoplastic Combined Chemotherapy Protocols

/ Child