Journal Article

Maternal smoking and neurodevelopmental outcomes in infants <29 weeks gestation: a multicenter cohort study

Levebrve Francine, Lee, Shoo K, Moddemann Diane, Ruben, Alvaro, Isayama Tetsuya, Yee, Wendy, Bizgu Victoria, Ly Linh, Ojah Cecil, Demers, Charlotte, Daboval Thierry, Pelausa Ermelinda, Bodani Jaya, Drolet, Christine, Bélanger Sylvie, Vincer, Michael, Bertelle Valerie, Da Silva Orlando, Reichert, Amber, Sherlock, Rebecca, Canning, Roderick, Kajetanowicz Andrzej, Afifi Jehier, Hasan, Shabih U, Dunn, Michael, Masse, Edith, Lee, David, Lee, Kyong-Soon, Creighton, Dianne, Barrington, Keith, Synnes, Anne, Chuks, Nwaesei, Ediger Krystyna, Makary Hala, Deshpandey Akhil, Fajardo, Carlos, Toye, Jennifer, Church, Paige, Shah, Prakesh S, Sibasis, Daspal, Dow, Kimberly, Shah, Jyotsna, Pillay Thevanisha, Murphy, Phil, Claveau Martine, Kalapesi Zarin, Sankaran Koravangattu, Monterrosa Luis, Piedboeuf Bruno, Cieslak Zenon, Ting, Joseph, Aziz, Khalid, Lemyre Brigitte, Sauvé Reg, Lodha Abhay, el Helou Salhab, Mukerji Amit, Beltempo Marc, Riley, Patricia, Harrison, Adele, Seshia, Mary, Kelly, Edmond

2019

Overview

ObjectiveTo compare neurodevelopmental outcomes of preterm infants at 18–21 months corrected age (CA) whose mothers smoked during pregnancy to those whose mothers did not smoke.Study designPreterm infants born at <29 weeks of gestation and evaluated at 18–21 months CA were included. Primary outcome was a composite outcome of death or neurodevelopmental impairment (NDI).ResultsOf a total of 2760 infants, 699 met exclusion criteria. Of the remaining 2061 infants, 280 (13.6%) were exposed to maternal smoking and 1781 (86.4%) were not. The odds of the composite outcome of death or NDI (aOR 1.40; 95% CI: 1.03–1.91), NDI alone (aOR 1.43; 95% CI: 1.01–2.03), and Bayley-III motor score <85 (aOR 1.91; 95% CI: 1.31–2.81) were higher in exposed infants.ConclusionsExposure to maternal smoking was associated with adverse composite outcome of death or NDI, NDI alone and lower motor scores at 18–21 months CA.

• Publisher: Nature Publishing Group
• Subject: Cohort analysis / Death / Exposure / Gestation / Infants / Mortality / Neurodevelopmental disorders / Newborn babies / Pregnancy / Smoke / Smoking